ReviewCurrent opinion in biotechnology2009
Chemical analysis in vivo and in vitro by Raman spectroscopy--from single cells to humans.
Review in Current opinion in biotechnology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 203 citations in OpenAlex.
- Evaluation of cadmium's impact on marine mussels: insights from Raman spectroscopy and chemometric analysis.Analytical and bioanalytical chemistry · 2026Article
- Advanced Image-Guidance and Surgical-Navigation Techniques for Real-Time Visualized Surgery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Spectroscopic Insights into the Localization and Photodynamic Efficacy of Aluminum Tetrasulfonated Phthalocyanine for Colorectal Cancer Therapy.The journal of physical chemistry. B · 2025Article
- Microbial consortia for the conversion of biomass into fuels and chemicals.Nature communications · 2025Review
- Establishment of a clinical workflow for in vivo Raman spectroscopy during head and neck cancer surgery.Scientific reports · 2025Article
- A Review on Perception of Binding Kinetics in Affinity Biosensors: Challenges and Opportunities.ACS omega · 2025Review
- Artificial Intelligence-Assisted Stimulated Raman Histology: New Frontiers in Vibrational Tissue Imaging.Cancers · 2024Review
- An in vitro assessment of the residual dentin after using three minimally invasive caries removal techniques.Scientific reports · 2024Article
- Direct laser induced writing of high precision gold nanosphere SERS patterns.Nanoscale advances · 2024Article
- Episymbiotic Saccharibacteria induce intracellular lipid droplet production in their host bacteria.The ISME journal · 2024Article
- Advances in Noninvasive Molecular Imaging Probes for Liver Fibrosis Diagnosis.Biomaterials research · 2024Review
- Extended Analysis of Raman Spectra Using Artificial Intelligence Techniques for Colorectal Abnormality Classification.Journal of imaging · 2023Article
- Determination of esophageal squamous cell carcinoma and gastric adenocarcinoma on raw tissue using Raman spectroscopy.World journal of gastroenterology · 2023Article
- Biochemical and Mechanical Analysis of Occlusal and Proximal Carious Lesions.Diagnostics (Basel, Switzerland) · 2022Article
- Review
- A Deep Learning Approach for Detecting Colorectal Cancer via Raman Spectra.BME frontiers · 2022Article
- Design and evaluation of Raman reporters for the Raman-silent region.Nanotheranostics · 2022Article
- Validity and reliability of Raman spectroscopy for carotenoid assessment in cattle skin.Biochemistry and biophysics reports · 2021Article
- Raman Spectroscopy Technique: A Non-Invasive Tool in Celiac Disease Diagnosis.Diagnostics (Basel, Switzerland) · 2021Article
- Raman spectroscopic detection of carotenoids in cattle skin.RSC advances · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The gold standard for clinical diagnostics of tissues is immunofluorescence staining. Toxicity of many fluorescent dyes precludes their application in vivo. Raman spectroscopy, a chemically specific, label-free diagnostic technique, is rapidly gaining acceptance as a powerful alternative. It has the ability to probe the chemical composition of biological materials in a non-destructive and mostly non-perturbing manner. We review the most recent developments in Raman spectroscopy in the life sciences, detailing advances in technology that have improved the ability to screen for diseases. Its role in the monitoring of biological function and mapping the cellular chemical microenvironment will be discussed. Applications including endoscopy, surface-enhanced Raman scattering (SERS), and coherent Raman scattering (CRS) will be reviewed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.