ReviewCurrent neurology and neuroscience reports2009
Neurometabolic disorders and dysfunction in autism spectrum disorders.
Review in Current neurology and neuroscience reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis.Molecular psychiatry · 2012Pooled it
- Diagnosis and Assessment of Autism Spectrum Disorder in South Korea.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2024Article
- Bioinformatics analysis of genomic and immune infiltration patterns in autism spectrum disorder.Annals of translational medicine · 2022Article
- Domain Adaptation Using a Three-Way Decision Improves the Identification of Autism Patients from Multisite fMRI Data.Brain sciences · 2021Article
- Clinical and biochemical footprints of inherited metabolic diseases. III. Psychiatric presentations.Molecular genetics and metabolism · 2020Review
- Vasopressin in the Amelioration of Social Functioning in Autism Spectrum Disorder.Journal of clinical medicine · 2019Review
- Review of Clinical Studies Targeting Inflammatory Pathways for Individuals With Autism.Frontiers in psychiatry · 2019Review
- Urine Organic Acids as Potential Biomarkers for Autism-Spectrum Disorder in Chinese Children.Frontiers in cellular neuroscience · 2019Article
- Audit of Organic Acidurias from a Single Centre: Clinical and Metabolic Profile at Presentation with Long Term Outcome.Journal of clinical and diagnostic research : JCDR · 2017Article
- Can psychiatric childhood disorders be due to inborn errors of metabolism?European child & adolescent psychiatry · 2017Review
- GWAS and transcriptional analysis prioritize ITPR1 and CNTN4 for a serum uric acid 3p26 QTL in Mexican Americans.BMC genomics · 2016Article
- Clinical Genetic Aspects of ASD Spectrum Disorders.International journal of molecular sciences · 2016Review
- Autism, Mitochondria and Polybrominated Diphenyl Ether Exposure.CNS & neurological disorders drug targets · 2016Review
- Chelation for autism spectrum disorder (ASD).The Cochrane database of systematic reviews · 2015Article
- Pathologies in functional connectivity, feedback control and robustness: a global workspace perspective on autism spectrum disorders.Cognitive processing · 2015Review
- Genetic diagnosis of autism spectrum disorders: the opportunity and challenge in the genomics era.Critical reviews in clinical laboratory sciences · 2014Review
- Autism spectrum disorder: advances in evidence-based practice.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2014Review
- Potential therapeutic use of the ketogenic diet in autism spectrum disorders.Frontiers in pediatrics · 2014Review
- The diverse genetic landscape of neurodevelopmental disorders.Annual review of genomics and human genetics · 2014Review
- Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders.Molecular autism · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cause of autism remains largely unknown because it is likely multifactorial, arising from the interaction of biologic, genetic, and environmental factors. The specific role of metabolic abnormalities also is largely unknown, but current research may provide insight into the pathophysiologic underpinnings of autism, at least in some patients. We review a number of known neurometabolic disorders identified as having an autistic phenotype. We also discuss the possible involvement of mitochondrial disorders and dysfunction as well as a theory regarding an increased vulnerability to oxidative stress, by which various environmental toxins produce metabolic alterations that impair normal cellular function. Finally, we review various strategies for metabolic work-up and treatment. Accurate diagnosis of neurometabolic disorders and a broader understanding of underlying metabolic disturbance even in the absence of known disease have important implications both for individual patients and for research into the etiology of autism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.