ReviewCellular and molecular biology (Noisy-le-Grand, France)2009
5-aminolevulinate synthase: catalysis of the first step of heme biosynthesis.
Review in Cellular and molecular biology (Noisy-le-Grand, France), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Recent advances in microbial fermentation for the production of leghemoglobin.World journal of microbiology & biotechnology · 2025Review
- Genomic Insights into Vector-Pathogen Adaptation inPathogens (Basel, Switzerland) · 2025Article
- Versatile Chemo-Biocatalytic Cascade Driven by a Thermophilic and Irreversible C-C Bond-Forming α-Oxoamine Synthase.ACS sustainable chemistry & engineering · 2023Article
- Engineering Escherichia coli for efficient assembly of heme proteins.Microbial cell factories · 2023Article
- Ferroptosis and Its Emerging Role in Pre-Eclampsia.Antioxidants (Basel, Switzerland) · 2022Review
- 2-Aminoacrylate stress damages diverse PLP-dependent enzymes in vivo.The Journal of biological chemistry · 2022Article
- Perturbations in the Heme and Siroheme Biosynthesis Pathways Causing Accumulation of Fluorescent Free Base Porphyrins and Auxotrophy inJournal of fungi (Basel, Switzerland) · 2021Article
- RNA Interference by Ingested Dsrna-Expressing Bacteria to Study Porphyrin Pigmentation inInternational journal of molecular sciences · 2021Article
- Article
- Semi-rational approach to expand the Acyl-CoA Chain length tolerance of Sphingomonas paucimobilis serine palmitoyltransferase.Enzyme and microbial technology · 2020Article
- Review
- Anti-Correlation between the Dynamics of the Active Site Loop and C-Terminal Tail in Relation to the Homodimer Asymmetry of the Mouse Erythroid 5-Aminolevulinate Synthase.International journal of molecular sciences · 2018Article
- Intracellular iron and heme trafficking and metabolism in developing erythroblasts.Metallomics : integrated biometal science · 2017Review
- Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product.Microbiology and molecular biology reviews : MMBR · 2017Review
- Human Erythroid 5-Aminolevulinate Synthase Mutations Associated with X-Linked Protoporphyria Disrupt the Conformational Equilibrium and Enhance Product Release.Biochemistry · 2015Article
- Microcytic anemia in a pregnant woman: beyond iron deficiency.International journal of hematology · 2015Article
- ATP-binding cassette B10 regulates early steps of heme synthesis.Circulation research · 2013Article
- Hemin augments growth and hemoglobinization of erythroid precursors from patients with diamond-blackfan anemia.Anemia · 2012Article
- Molecular enzymology of 5-aminolevulinate synthase, the gatekeeper of heme biosynthesis.Biochimica et biophysica acta · 2011Review
- A novel pathway for the biosynthesis of heme in Archaea: genome-based bioinformatic predictions and experimental evidence.Archaea (Vancouver, B.C.) · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
5-Aminolevulinate synthase is a homodimeric pyridoxal 5'-phosphate-dependent enzyme that catalyzes the first step of the heme biosynthetic pathway in animals, fungi, and the alpha-subclass of the photosynthetic purple bacteria. The reaction cycle involves condensation of glycine with succinyl-coenzyme A to yield 5-aminolevulinate, carbon dioxide, and CoA. Mutations in the human erythroid-specific aminolevulinate synthase gene are associated with the erythropoietic disorder X-linked sideroblastic anemia. Recent kinetic and crystallographic data have facilitated an unprecedented understanding of how this important enzyme produces 5-aminolevulinate, and suggest possible directions for future research that may lead to treatments not only for X-linked sideroblastic anemia, but also other diseases.
Indexed as
Identifiers
19268008PMC2864774W1587685062What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.