ArticleNeuron glia biology2008
Activity-dependent neuron-glial signaling by ATP and leukemia-inhibitory factor promotes hippocampal glial cell development.
Article in Neuron glia biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
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- The role of purinergic receptors in neural repair and regeneration after spinal cord injury.Neural regeneration research · 2023Review
- Neurons Induce Tiled Astrocytes with Branches That Avoid Each Other.International journal of molecular sciences · 2022Article
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- Buyang Huanwu Decoction () Attenuates Glial Scar by Downregulating the Expression of Leukemia Inhibitory Factor in Intracerebral Hemorrhagic Rats.Chinese journal of integrative medicine · 2019Article
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- Extracellular ATP and other nucleotides-ubiquitous triggers of intercellular messenger release.Purinergic signalling · 2016Review
- Purinergic signalling during development and ageing.Purinergic signalling · 2015Review
- Extrinsic purinergic regulation of neural stem/progenitor cells: implications for CNS development and repair.Stem cell reviews and reports · 2012Review
- Plasticity in gray and white: neuroimaging changes in brain structure during learning.Nature neuroscience · 2012Review
- LIF-dependent signaling: new pieces in the Lego.Stem cell reviews and reports · 2012Review
- MicroRNA regulation of homeostatic synaptic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Chronic vs. acute interactions between supraoptic oxytocin neurons and astrocytes during lactation: role of glial fibrillary acidic protein plasticity.TheScientificWorldJournal · 2009Review
- Leukemia inhibitory factor regulates the timing of oligodendrocyte development and myelination in the postnatal optic nerve.Journal of neuroscience research · 2009Article
- Endogenous leukemia inhibitory factor protects photoreceptor cells against light-induced degeneration.Molecular vision · 2009Article
- Regulation of myelin genes implicated in psychiatric disorders by functional activity in axons.Frontiers in neuroanatomy · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Activity-dependent signaling between neurons and astrocytes contributes to experience-dependent plasticity and development of the nervous system. However, mechanisms responsible for neuron-glial interactions and the releasable factors that underlie these processes are not well understood. The pro-inflammatory cytokine, leukemia-inhibitory factor (LIF), is transiently expressed postnatally by glial cells in the hippocampus and rapidly up-regulated by enhanced neural activity following seizures. To test the hypothesis that spontaneous neural activity regulates glial development in hippocampus via LIF signaling, we blocked spontaneous activity with the sodium channel blocker tetrodotoxin (TTX) in mixed hippocampal cell cultures in combination with blockers of LIF and purinergic signaling. TTX decreased the number of GFAP-expressing astrocytes in hippocampal cell culture. Furthermore, blocking purinergic signaling by P2Y receptors contributed to reduced numbers of astrocytes. Blocking activity or purinergic signaling in the presence of function-blocking antibodies to LIF did not further decrease the number of astrocytes. Moreover, hippocampal cell cultures prepared from LIF -/- mice had reduced numbers of astrocytes and activity-dependent neuron-glial signaling promoting differentiation of astrocytes was absent. The results show that endogenous LIF is required for normal development of hippocampal astrocytes, and this process is regulated by spontaneous neural impulse activity through the release of ATP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.