ReviewThe journal of sexual medicine2009
Potential of adipose-derived stem cells for treatment of erectile dysfunction.
Review in The journal of sexual medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 80 citations in OpenAlex.
- Adipose-Derived Mesenchymal Stem Cells Alleviate ᴅ-Galactose-Induced Testicular Injury by Activating the Keap1/Nrf2 Pathway and Suppressing NLRP3-Associated Pyroptosis.Antioxidants (Basel, Switzerland) · 2026Article
- Advances in stem cell therapy for erectile dysfunction: preclinical evidence and emerging therapeutic approaches.Frontiers in medicine · 2025Review
- An update on the use of stem cell therapy for erectile dysfunction.Asian journal of urology · 2024Review
- Mesenchymal stem cell secretome: A promising therapeutic strategy for erectile dysfunction?Asian journal of urology · 2024Review
- ADSCs labeled with SPIONs tracked in corpus cavernosum of rat and miniature pig by MR imaging and histological examination.Scientific reports · 2024Article
- The use of low-intensity extracorporeal shockwave therapy in management of erectile dysfunction following prostate cancer treatment: a review of the current literature.Translational andrology and urology · 2023Review
- Stem Cell Therapy for Erectile Dysfunction: A Step towards a Future Treatment.Life (Basel, Switzerland) · 2023Review
- Intracavernous Injection of Platelet-Rich Plasma Therapy Enhances Erectile Function and Decreases the Mortality Rate in Streptozotocin-Induced Diabetic Rats.International journal of molecular sciences · 2022Article
- Comparison of the therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells and adipose-derived stem cells on erectile dysfunction in a rat model of bilateral cavernous nerve injury.Frontiers in bioengineering and biotechnology · 2022Article
- Article
- Erectile Dysfunction Treatment Using Stem Cells: A Review.Medicines (Basel, Switzerland) · 2021Review
- Mesenchymal stem cell therapy improves erectile dysfunction in experimental spinal cord injury.International journal of impotence research · 2020Article
- Development of nanotechnology in andrology.Translational andrology and urology · 2020Review
- Neural-like cells from adipose-derived stem cells for cavernous nerve injury in rats.Neural regeneration research · 2019Article
- Smooth Muscle Progenitor Cells Preserve the Erectile Function by Reducing Corporal Smooth Muscle Cell Apoptosis after Bilateral Cavernous Nerve Crush Injury in Rats.BioMed research international · 2019Article
- Mesenchymal stem cell-based gene therapy for erectile dysfunction.International journal of impotence research · 2016Review
- Erectile dysfunction.Nature reviews. Disease primers · 2016Review
- Adipose Tissue-Derived Stem Cells for the Treatment of Erectile Dysfunction.Current urology reports · 2016Review
- Comparative study of autologous stromal vascular fraction and adipose-derived stem cells for erectile function recovery in a rat model of cavernous nerve injury.Stem cells translational medicine · 2015Article
- Virus integration and genome influence in approaches to stem cell based therapy for andro-urology.Advanced drug delivery reviews · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionAdipose-derived stem cells (ADSCs) are a somatic stem cell population contained in fat tissue that possess the ability for self-renewal, differentiation into one or more phenotypes, and functional regeneration of damaged tissue, which may benefit the recovery of erectile function by using a stem cell-based therapy.
aimTo review available evidence concerning ADSCs availability, differentiation into functional cells, and the potential of these cells for the treatment of erectile dysfunction (ED).
methodsWe examined the current data (from 1964 to 2008) associated with the definition, characterization, differentiation, and application of ADSCs, as well as other kinds of stem cells for the cell-based therapies of ED.
main outcome measuresThere is strong evidence supporting the concept that ADSCs may be a potential stem cell therapy source in treating ED.
resultsThe ADSCs are paravascularly localized in the adipose tissue. Under specific induction medium conditions, these cells differentiated into neuron-like cells, smooth muscle cells, and endothelium in vitro. The insulin-like growth factor/insulin-like growth factor receptor (IGF/IGFR) pathway participates in neuronal differentiation while the fibroblast growth factor 2 (FGF2) pathway is involved in endothelium differentiation. In a preliminary in vivo experiment, the ADSCs functionally recovered the damaged erectile function. However, the underlying mechanism needs to be further examined.
conclusionThe ADSCs are a potential source for stem cell-based therapies, which imply the possibility of an effective clinical therapy for ED in the near future.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.