ArticleVirchows Archiv. A, Pathological anatomy and histopathology1991
Candidiasis visualised by proteinase-directed immunofluorescence.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 43 citations in OpenAlex.
- Saps1-3 Antigens inInfectious disease reports · 2024Article
- The Inflammatory response induced by aspartic proteases of Candida albicans is independent of proteolytic activity.Infection and immunity · 2010Article
- HIV aspartyl protease inhibitors as promising compounds against Candida albicans André Luis Souza dos Santos.World journal of biological chemistry · 2010Article
- Polyene susceptibility is dependent on nitrogen source in the opportunistic pathogen Candida albicans.The Journal of antimicrobial chemotherapy · 2008Article
- Candida albicans secreted aspartyl proteinases in virulence and pathogenesis.Microbiology and molecular biology reviews : MMBR · 2003Review
- Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs.Infection and immunity · 2002Article
- Secreted aspartic proteinase family of Candida tropicalis.Infection and immunity · 2001Article
- In vivo analysis of secreted aspartyl proteinase expression in human oral candidiasis.Infection and immunity · 1999Article
- Cell wall and secreted proteins of Candida albicans: identification, function, and expression.Microbiology and molecular biology reviews : MMBR · 1998Review
- Serologic response to cell wall mannoproteins and proteins of Candida albicans.Clinical microbiology reviews · 1998Review
- A triple deletion of the secreted aspartyl proteinase genes SAP4, SAP5, and SAP6 of Candida albicans causes attenuated virulence.Infection and immunity · 1997Article
- Expression of Candida albicans SAP1 and SAP2 in experimental vaginitis.Infection and immunity · 1995Article
- Degradation of humoral host defense by Candida albicans proteinase.Infection and immunity · 1995Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The secretory aspartic proteinases of Candida albicans and C. tropicalis are potential factors for virulence produced during infection. By indirect immunofluorescence, we have demonstrated proteinase antigen on elements of both species in deparaffinized tissue sections derived from clinical cases of mucosal and deep-seated candidiasis. Occasionally, we observed a halo of fluorescence in the close vicinity of candidal cells, which may reflect secretion of the enzyme. In kidneys, a ring of amorphous fluorescent material surrounding candidal colonies may illustrate alkaline denaturation of secreted enzyme within a pH gradient, which is generated by the fungus. Our findings support the view that candidal proteinase may be a diagnostically relevant antigen.
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