ArticleRadiation research2009
Chronic oxidative stress as a mechanism for radiation nephropathy.
Article in Radiation research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Oral alkalinizing supplementation suppressed intrarenal reactive oxidative stress in mild-stage chronic kidney disease: a randomized cohort study.Clinical and experimental nephrology · 2024Trial
- Early diagnosis of radiation-induced renal injury: from lagging indicators to multimodal, pre-fibrotic detection.Frontiers in cell and developmental biology · 2026Review
- Effects of Concurrent Exposure to Chronic Restraint-Induced Stress and Total-Body Iron Ion Radiation on Induction of Kidney Injury in Mice.International journal of molecular sciences · 2022Article
- Radiation-induced kidney toxicity: molecular and cellular pathogenesis.Radiation oncology (London, England) · 2021Review
- In vivo AAV delivery of glutathione reductase gene attenuates anti-aging gene klotho deficiency-induced kidney damage.Redox biology · 2020Article
- Cardiac and Renal Delayed Effects of Acute Radiation Exposure: Organ Differences in Vasculopathy, Inflammation, Senescence and Oxidative Balance.Radiation research · 2019Article
- The effects of lipoic acid on redox status in brain regions and systemic circulation in streptozotocin-induced sporadic Alzheimer's disease model.Metabolic brain disease · 2017Article
- Effects of Fenton Reaction on Human Serum Albumin: An In Vitro Study.Electronic physician · 2016Article
- Radiation-induced afferent arteriolar endothelial-dependent dysfunction involves decreased epoxygenase metabolites.American journal of physiology. Heart and circulatory physiology · 2016Article
- Epoxyeicosatrienoic acid analogue mitigates kidney injury in a rat model of radiation nephropathy.Clinical science (London, England : 1979) · 2016Article
- Relation between Endothelial Nitric Oxide Synthase Genotypes and Oxidative Stress Markers in Larynx Cancer.Oxidative medicine and cellular longevity · 2016Article
- Model development and use of ACE inhibitors for preclinical mitigation of radiation-induced injury to multiple organs.Radiation research · 2014Article
- A comprehensive study of myocardial redox homeostasis in naturally and mimetically aged rats.Age (Dordrecht, Netherlands) · 2014Article
- Article
- Chronic oxidative stress after irradiation: An unproven hypothesis.Medical hypotheses · 2013Review
- Evaluation of Genomic Evidence for Oxidative Stress in Experimental Radiation Nephropathy.Journal of genetic disorders & genetic reports · 2013Article
- Radiation-induced chronic oxidative renal damage can be reduced by amifostine.Medical oncology (Northwood, London, England) · 2012Article
- Exposure to heavy ion radiation induces persistent oxidative stress in mouse intestine.PloS one · 2012Article
- Induction of oxidative stress in kidney.International journal of nephrology · 2012Article
- Salen Mn complexes mitigate radiation injury in normal tissues.Anti-cancer agents in medicinal chemistry · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Suppression of the renin-angiotensin system has proven efficacy for mitigation and treatment of radiation nephropathy, and it has been hypothesized that this efficacy is due to suppression of radiation-induced chronic oxidative stress. It is known that radiation exposure leads to acute oxidative stress, but direct evidence for radiation-induced chronic renal oxidative stress is sparse. We looked for evidence of oxidative stress after total-body irradiation in a rat model, focusing on the period before there is physiologically significant renal damage. No statistically significant increase in urinary 8-isoprostane (a marker of lipid peroxidation) or carbonylated proteins (a marker of protein oxidation) was found over the first 42 days after irradiation, while a small but statistically significant increase in urinary 8-hydroxydeoxy-guanosine (a marker of DNA oxidation) was detected at 35-55 days. When we examined renal tissue from these animals, we found no significant increase in either DNA or protein oxidation products over the first 89 days after irradiation. Using five different standard methods for detecting oxidative stress in vivo, we found no definitive evidence for radiation-induced renal chronic oxidative stress. If chronic oxidative stress is part of the pathogenesis of radiation nephropathy, it does not leave widespread or easily detectable evidence behind.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.