ArticleJournal of proteome research2009
Platelet proteome changes associated with diabetes and during platelet storage for transfusion.
Article in Journal of proteome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 60 citations in OpenAlex.
- Glycemic control and blood product quality of Canadian blood donors with diabetes.Transfusion · 2026Article
- SEC61B regulates calcium flux and platelet hyperreactivity in diabetes.The Journal of clinical investigation · 2025Article
- Article
- Current Strategies to Guide the Antiplatelet Therapy in Acute Coronary Syndromes.International journal of molecular sciences · 2024Review
- Review
- In Vitro Exposure to Glucose Alters the Expression of Phosphorylated Proteins in Platelets.Biomedicines · 2023Article
- Resveratrol; a Double-Edged Sword Antioxidant Agent for Preserving Platelet Cell Functions During Storage; Molecular Insights.Reports of biochemistry & molecular biology · 2023Article
- Functional annotation and enrichment analysis of differentially expressed serum proteins in patients with type 2 diabetes after dapagliflozin.World journal of diabetes · 2022Article
- The canine activated platelet secretome (CAPS): A translational model of thrombin-evoked platelet activation response.Research and practice in thrombosis and haemostasis · 2021Article
- Evaluation of platelet activation in leukocyte-depleted platelet concentrates during storage.Bosnian journal of basic medical sciences · 2018Article
- Temperature effects on the activity, shape, and storage of platelets from 13-lined ground squirrels.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
- Resveratrol preserves the function of human platelets stored for transfusion.British journal of haematology · 2016Article
- Combining patient proteomics and in vitro cardiomyocyte phenotype testing to identify potential mediators of heart failure with preserved ejection fraction.Journal of translational medicine · 2016Article
- Platelet transfusion - the new immunology of an old therapy.Frontiers in immunology · 2015Review
- The hibernating 13-lined ground squirrel as a model organism for potential cold storage of platelets.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Platelet proteomics in transfusion medicine: a reality with a challenging but promising future.Blood transfusion = Trasfusione del sangue · 2012Article
- Platelet storage and transfusions: new concerns associated with an old therapy.Drug discovery today. Disease mechanisms · 2011Article
- Transfusion medicine and proteomics. Alliance or coexistence?Blood transfusion = Trasfusione del sangue · 2010Review
- Real-Time Live Confocal Fluorescence Microscopy as a New Tool for Assessing Platelet Vitality.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
Human platelets play a key role in hemostasis and thrombosis and have recently emerged as key regulators of inflammation. Platelets stored for transfusion produce pro-thrombotic and pro-inflammatory mediators implicated in adverse transfusion reactions. Correspondingly, these mediators are central players in pathological conditions including cardiovascular disease, the major cause of death in diabetics. In view of this, a mass spectrometry based proteomics study was performed on platelets collected from healthy and type-2 diabetics stored for transfusion. Strikingly, our innovative and sensitive proteomic approach identified 122 proteins that were either up- or down-regulated in type-2 diabetics relative to nondiabetic controls and 117 proteins whose abundances changed during a 5-day storage period. Notably, our studies are the first to characterize the proteome of platelets from diabetics before and after storage for transfusion. These identified differences allow us to formulate new hypotheses and experimentation to improve clinical outcomes by targeting "high risk platelets" that render platelet transfusion less effective or even unsafe.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.