Evidence map›Paper›PMID 19267370›Full record

ArticleThe Prostate2009

Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II.

Ming-Hsi Wang, Kathy J Helzlsouer, Michael W Smith, Judith A Hoffman-Bolton, Sandra L Clipp, Viktoriya Grinberg, Angelo M De Marzo, William B Isaacs, Charles G Drake, Yin Yao Shugart and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Prostate, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 25 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 25 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 25 syntheses or guidelines pooled it, 119 citations in OpenAlex.

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  8. Causal relevance of circulating adiponectin with cancer: a meta-analysis implementing Mendelian randomization.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
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  9. Association of LEP A19G polymorphism with cancer risk: a systematic review and pooled analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
    Pooled it
  10. The polymorphism interleukin-8 -251A/T is associated with a significantly increased risk of cancers from a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
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  14. LEP gene variant is associated with prostate cancer but not with colorectal cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013
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  16. Three adiponectin rs1501299G/T, rs822395A/C, and rs822396A/G polymorphisms and risk of cancer development: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Ming-Hsi WangDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA.
Kathy J Helzlsouer
Michael W Smith
Judith A Hoffman-Bolton
Sandra L Clipp
Viktoriya Grinberg
Angelo M De Marzo
William B Isaacs
Charles G Drake
Yin Yao Shugart
Elizabeth A Platz
Johns Hopkins University · USScience Applications International Corporation (United States) · USSidney Kimmel Comprehensive Cancer Center · USHagerstown Community College · USMercy Medical Center · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
TRANSGENIC MODELS FOR PROSTATE CANCER AND AUTOIMMUNITYP50CA058236 · NCI · JOHNS HOPKINS UNIVERSITY · PI DENMEADE, SAMUEL R · 1992 to 2020
$43.9M
CLUE STUDIES--EVALUATING BIOMARKERS OF CARCINOGENESISU01CA086308 · NCI · JOHNS HOPKINS UNIVERSITY · PI HELZLSOUER, KATHY J · 2000 to 2004
$4.2M
GENE-ENVIRONMENT INTERACTIONS: THE ODYSSEY COHORTU01AG018033 · NIA · JOHNS HOPKINS UNIVERSITY · PI HOFFMAN, SANDRA · 1999 to 2003
$2.8M
NCI NIH HHS N01 CO012400NCI NIH HHS P30 CA006973NCI NIH HHS P50 CA058236NCI NIH HHS P50 CA 58236NCI NIH HHS U01 CA086308NCI NIH HHS U01 CA 86308NIA NIH HHS U01 AG018033NIA NIH HHS U01 AG 18033
6 · The paper itself

Abstract

backgroundChronic intra-prostatic inflammation and obesity are thought to influence prostate carcinogenesis. Thus, variants in genes in these pathways could be associated with prostate cancer risk.

methodsWe genotyped 17 common single nucleotide polymorphisms (SNPs) in RNASEL, TLR4, IL1B, IL6, IL8, IL10, TNF, CRP, ADIPOQ, LEP, PPARG, and TCF7L2 in 258 white prostate cancer cases and 258 matched controls nested in CLUE II. Single-locus analyses were conducted using conditional logistic regression. TagSNPs were selected in IL10, CRP, and TLR4 and haplotype analyses were done.

resultsThe A allele of IL10 -1082G>A (rs1800896), known to result in lower levels of this anti-inflammatory cytokine, was positively associated with risk (AG vs. GG, OR = 1.69, 95% CI: 1.10-2.60; AA vs. GG, OR = 1.81, 95% CI: 1.11-2.96; P (trend) = 0.02). Associations of IL10 haplotypes with prostate cancer were explained by high linkage disequilibrium between two tagSNPs (rs1800890 and rs3024496) and -1082G>A. A TLR4 candidate SNP (rs4986790; AG/GG vs. AA, OR = 0.60, 95% CI: 0.33-1.08; P(trend) = 0.09), known to have decreased expression and be associated with lower circulating levels of inflammatory mediators, and tagSNP (rs10116253; CC vs. TT, OR = 3.05, 95% CI: 1.11-8.41), but not haplotypes, were associated with risk. None of the other candidate SNPs or haplotypes was statistically significantly associated with risk.

conclusionOur prospective study suggests that genetic variation in IL10 and possibly TLR4 is associated with prostate cancer risk. Although none of the SNPs in the obesity genes tested was associated, this does not rule out a complex role of obesity and its metabolic consequences in prostate cancer etiology.

Indexed as

Genetic VariationPolymorphism, Single NucleotideAdultCase-Control StudiesCohort StudiesC-Reactive ProteinEndoribonucleasesExonsFemaleHumansInterleukin-10InterleukinsIntronsLeptinMaleMiddle Aged2-5A-dependent ribonucleaseC-Reactive ProteinEndoribonucleasesInterleukin-10InterleukinsLeptinPPAR gammaTLR4 protein, humanToll-Like Receptor 4

Identifiers

PMID19267370
PMCPMC3016874
OpenAlexW2057668066

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.