ArticleThe Prostate2009
Sequence variation in the mitochondrial gene cytochrome c oxidase subunit I and prostate cancer in African American men.
Article in The Prostate, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Mitochondrial Complex I Molecular Alterations in Sapajus apella as a Human Gastric Carcinogenesis Model After MNU Exposure.Journal of medical primatology · 2025Article
- Mitochondrial Alterations in Prostate Cancer: Roles in Pathobiology and Racial Disparities.International journal of molecular sciences · 2023Review
- The Role of Mitochondria in Carcinogenesis.International journal of molecular sciences · 2021Review
- Detection of novel mitochondrial mutations in cytochrome C oxidase subunit 1 (COX1) in patients with familial adenomatous polyposis (FAP).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020Article
- The Role of Aberrant Metabolism in Cancer: Insights Into the Interplay Between Cell Metabolic Reprogramming, Metabolic Syndrome, and Cancer.Frontiers in oncology · 2020Review
- CytochromeCancer research · 2019Article
- The MT-CO1 V83I Polymorphism is a Risk Factor for Primary Open-Angle Glaucoma in African American Men.Investigative ophthalmology & visual science · 2018Article
- Identification of sequence polymorphisms in the mitochondrial cytochrome c oxidase genes as risk factors for hepatocellular carcinoma.Journal of clinical laboratory analysis · 2018Article
- Mitochondrial determinants of cancer health disparities.Seminars in cancer biology · 2017Review
- Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk.Human molecular genetics · 2016Article
- Association of primary open-angle glaucoma with mitochondrial variants and haplogroups common in African Americans.Molecular vision · 2016Article
- No association between typical European mitochondrial variation and prostate cancer risk in a Spanish cohort.Journal of human genetics · 2014Article
- Small Circular DNAs in Human Pathology.The Malaysian journal of medical sciences : MJMS · 2014Article
- Cloning and expression analysis of the gastric carcinoma-related gene, ELCOX3.Oncology letters · 2013Article
- An inherited heteroplasmic mutation in mitochondrial gene COI in a patient with prostate cancer alters reactive oxygen, reactive nitrogen and proliferation.BioMed research international · 2013Article
- Mitochondrial Cytochrome c Oxidase subunit 1 Sequence Variation in Prostate Cancer.Scientifica · 2012Article
- Mitochondrial dysfunction impairs tumor suppressor p53 expression/function.The Journal of biological chemistry · 2011Article
- The role of the mitochondrial genome in ageing and carcinogenesis.Journal of aging research · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPrevious studies have found associations between mitochondrial DNA (mtDNA) mutations and several cancer types. Recently, we found that mutations in the mtDNA gene cytochrome c oxidase subunit 1 (COI) were both linked to and associated with prostate cancer (PCa) in Caucasian men. Here we examine the association between COI mutations and PCa in African American men.
methodsThe entire COI gene was directly sequenced in 132 PCa cases and 135 controls from the Flint Men's Health Study, a community-based sample of African American men with and without PCa. Associations between all variants and PCa were evaluated.
resultsWe identified 102 COI single nucleotide polymorphisms (SNPs), including 15 missense variants. Overall, the presence of one or more COI missense variants was not significantly associated with PCa. Individually, two SNPs (T6221C and T7389C) were significantly associated with prostate cancer (P < 0.05) and in strong linkage disequilibrium with each other (r(2) > 0.6).
conclusionsOf the two significantly associated SNPs, one is a synonymous substitution and the other is part of the African-specific mitochondrial haplogroup (L). Additional research will be needed to determine the clinical relevance of these associations in African populations.
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