ArticleMolecular and cellular biochemistry2009
Altered gene expression may underlie prolonged duration of the QT interval and ventricular action potential in streptozotocin-induced diabetic rat heart.
Article in Molecular and cellular biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 25 citations in OpenAlex.
- SERCA2a stimulation by istaroxime improves intracellular Ca2+ handling and diastolic dysfunction in a model of diabetic cardiomyopathy.Cardiovascular research · 2022Article
- Electrocardiological effects of ranolazine and lidocaine on normal and diabetic rat atrium.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021Article
- Isolated downregulation of HCN2 in ventricles of rats with streptozotocin-induced diabetic cardiomyopathy.BMC cardiovascular disorders · 2021Article
- Early changes in myocyte contractility and cardiac function in streptozotocin-induced type 1 diabetes in rats.PloS one · 2020Article
- Cardiovascular Action of Insulin in Health and Disease: Endothelial L-Arginine Transport and Cardiac Voltage-Dependent Potassium Channels.Frontiers in physiology · 2016Review
- Different Profile of mRNA Expression in Sinoatrial Node from Streptozotocin-Induced Diabetic Rat.PloS one · 2016Article
- Glutathione oxidation unmasks proarrhythmic vulnerability of chronically hyperglycemic guinea pigs.American journal of physiology. Heart and circulatory physiology · 2013Article
- Myocardial impulse propagation is impaired in right ventricular tissue of Zucker diabetic fatty (ZDF) rats.Cardiovascular diabetology · 2013Article
- Simultaneous renal hypertension and type 2 diabetes exacerbate vascular endothelial dysfunction in rats.International journal of experimental pathology · 2012Article
- The effects of crocin, insulin and their co-administration on the heart function and pathology in streptozotocin-induced diabetic rats.Avicenna journal of phytomedicineArticle
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9 authors at 3 institutions in 2 countries.
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Abstract
Ventricular electrical conduction has been investigated in the streptozotocin (STZ)-induced diabetic rat. Diabetes was induced with a single injection of STZ (60 mg/kg bodyweight, ip). The ECG was measured continuously, in vivo, using a biotelemetry system. Left ventricular action potentials were recorded with an extracellular suction electrode. Expression of mRNA transcripts for selected ion transport proteins was measured in left ventricle with real-time RT-PCR. At 10 weeks after STZ treatment, in vivo heart rate (HR) was reduced (267 +/- 3 vs. 329 +/- 5 BPM), QRS complex duration and QT interval were prolonged in diabetic rats compared to controls. In vitro spontaneous HR was reduced and paced heart action potential repolarization was prolonged in diabetic rats compared to controls. The mRNA expression for Kcnd2 (I (to) channel) and Kcne2 (I (kr) channel) was significantly reduced in diabetic rats compared to controls. Altered gene expression and, in particular, genes that encode K(+) channel proteins may underlie delayed propagation of electrical activity in the ventricular myocardium of STZ-induced diabetic rat.
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