ArticlePharmaceutical research2009
Effects of ionic strength on passive and iontophoretic transport of cationic permeant across human nail.
Article in Pharmaceutical research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Lateral Transport in Anisotropic Membrane during Permeation Study in Diffusion Cell.Pharmaceutical research · 2026Article
- Lateral Transport During Membrane Permeation in Diffusion Cell: In Silico Study on Edge Effect and Membrane Blocking.Journal of pharmaceutical sciences · 2023Article
- Polishing the Therapy of Onychomycosis Induced byPharmaceutics · 2021Article
- Effect of pH on Iontophoretic Transport of Pramipexole Dihydrochloride across Human Epidermal Membrane.Pharmaceutical research · 2021Article
- Iontophoresis to Overcome the Challenge of Nail Permeation: Considerations and Optimizations for Successful Ungual Drug Delivery.The AAPS journal · 2021Review
- Optimization of Drug Permeation from 8% Ciclopirox Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers.Pharmaceutics · 2020Article
- Diffusion of uncharged solutes through human nail plate.Pharmaceutical development and technology · 2016Article
- Effects of organic solvents on the barrier properties of human nail.Journal of pharmaceutical sciences · 2011Article
- Influence of pH on transungual passive and iontophoretic transport.Journal of pharmaceutical sciences · 2010Article
- Time-dependent electrical properties of human nail upon hydration in vivo.Journal of pharmaceutical sciences · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
purposeTransport across the human nail under hydration can be modeled as hindered transport across aqueous pore pathways. As such, nail permselectivity to charged species can be manipulated by changing the ionic strength of the system in transungual delivery to treat nail diseases. The present study investigated the effects of ionic strength upon transungual passive and iontophoretic transport.
methodsTransungual passive and anodal iontophoretic transport experiments of tetraethylammonium ion (TEA) were conducted under symmetric conditions in which the donor and receiver had the same ionic strength in vitro. Experiments under asymmetric conditions were performed to mimic the in vivo conditions. Prior to the transport studies, TEA uptake studies were performed to assess the partitioning of TEA into the nail.
resultsPermselectivity towards TEA was inversely related to ionic strength in both passive and iontophoretic transport. The permeability and transference number of TEA were higher at lower ionic strengths under the symmetric conditions due to increased partitioning of TEA into the nail. Transference numbers were smaller under the asymmetric conditions compared with their symmetric counterparts.
conclusionsThe results demonstrate significant ionic strength effects upon the partitioning and transport of a cationic permeant in transungual transport, which may be instrumental in the development of transungual delivery systems.
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