ArticleThe Journal of comparative neurology2009
Birth of ophthalmic trigeminal neurons initiates early in the placodal ectoderm.
Article in The Journal of comparative neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Elp1 function in placode-derived neurons is critical for proper trigeminal ganglion development.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- N-cadherin facilitates trigeminal sensory neuron outgrowth and target tissue innervation.Development (Cambridge, England) · 2025Article
- The transcriptional landscape of the developing chick trigeminal ganglion.Developmental biology · 2025Article
- Tlx3 mediates neuronal differentiation and proper condensation of the developing trigeminal ganglion.Developmental biology · 2024Article
- Neurogenin 2 and Neuronal Differentiation 1 Control Proper Development of the Chick Trigeminal Ganglion and Its Nerve Branches.Journal of developmental biology · 2023Article
- Primary sensory map formations reflect unique needs and molecular cues specific to each sensory system.F1000Research · 2019Review
- Human iPSC-derived trigeminal neurons lack constitutive TLR3-dependent immunity that protects cortical neurons from HSV-1 infection.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Generating retinoic acid gradients by local degradation during craniofacial development: One cell's cue is another cell's poison.Genesis (New York, N.Y. : 2000) · 2018Review
- Identification of molecular signatures specific for distinct cranial sensory ganglia in the developing chick.Neural development · 2016Article
- Changes in gene expression and cell shape characterise stages of epibranchial placode-derived neuron maturation in the chick.Journal of anatomy · 2015Article
- Signaling mechanisms controlling cranial placode neurogenesis and delamination.Developmental biology · 2014Review
- Cranial neural crest cells form corridors prefiguring sensory neuroblast migration.Development (Cambridge, England) · 2013Article
- The origin and evolution of the ectodermal placodes.Journal of anatomy · 2013Review
- An effective assay for high cellular resolution time-lapse imaging of sensory placode formation and morphogenesis.BMC neuroscience · 2011Article
- Tetraspanin, CD151, is required for maintenance of trigeminal placode identity.Journal of neurochemistry · 2011Article
- Sensory neuron differentiation is regulated by notch signaling in the trigeminal placode.Developmental biology · 2010Article
- Apoptosis and proliferation in the trigeminal placode.Brain structure & function · 2009Article
- Molecular and tissue interactions governing induction of cranial ectodermal placodes.Developmental biology · 2009Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The largest of the cranial ganglia, the trigeminal ganglion, relays cutaneous sensations of the head to the central nervous system. Its sensory neurons have a dual origin from both ectodermal placodes and neural crest. Here, we show that the birth of neurons derived from the chick ophthalmic trigeminal placode begins prior to their ingression (HH11), as early as HH8, and considerably earlier than previously suspected (HH16). Furthermore, cells exiting the cell cycle shortly thereafter express the ophthalmic trigeminal placode marker Pax3 (HH9). At HH11, these postmitotic Pax3+ placode cells begin to express the pan-neuronal marker neurofilament while still in the ectoderm. Analysis of the ectodermal origin and distribution of these early postmitotic neurons reveals that the ophthalmic placode extends further rostrally than anticipated, contributing to neurons that reside in and make a significant contribution to the ophthalmic trigeminal nerve. These data redefine the timing and extent of neuron formation from the ophthalmic trigeminal placode.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.