ArticleAngewandte Chemie (International ed. in English)2009
Conformationally homogeneous heterocyclic pseudotetrapeptides as three-dimensional scaffolds for rational drug design: receptor-selective somatostatin analogues.
Article in Angewandte Chemie (International ed. in English), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Chemoselective, regioselective, and positionally selective fluorogenic stapling of unprotected peptides for cellular uptake and direct cell imaging.Chemical science · 2025Article
- Macrocyclic Triazolopeptoids: A Promising Class of Extended Cyclic Peptoids.Organic letters · 2022Article
- Molecular Self-Assembly and Supramolecular Chemistry of Cyclic Peptides.Chemical reviews · 2021Review
- 1,2,3-Triazoles as Biomimetics in Peptide Science.Molecules (Basel, Switzerland) · 2021Review
- 1,4-Disubstituted 1,2,3-Triazoles as Amide Bond Surrogates for the Stabilisation of Linear Peptides with Biological Activity.Molecules (Basel, Switzerland) · 2020Review
- Tailored therapeutics based on 1,2,3-1MedChemComm · 2019Review
- 1,4-Disubstituted 1Frontiers in chemistry · 2019Article
- Synthesis of novel cyclopeptides containing heterocyclic skeletons.RSC advances · 2018Review
- Oxadiazole grafts in peptide macrocycles.Nature chemistry · 2016Article
- Anthranilic acid-containing cyclic tetrapeptides: at the crossroads of conformational rigidity and synthetic accessibility.Organic & biomolecular chemistry · 2016Article
- Bridged bicyclic peptides as potential drug scaffolds: synthesis, structure, protein binding and stability.Chemical science · 2015Article
- Peptide conjugation via CuAAC 'click' chemistry.Molecules (Basel, Switzerland) · 2013Article
- Systematic replacement of amides by 1,4-disubstituted[1,2,3]triazoles in Leu-enkephalin and the impact on the delta opioid receptor activity.Bioorganic & medicinal chemistry letters · 2013Article
- Click chemistry in peptide-based drug design.Molecules (Basel, Switzerland) · 2013Review
- Macrocyclic peptoid-Peptide hybrids as inhibitors of class I histone deacetylases.ACS medicinal chemistry letters · 2012Article
- Strained cyclophane macrocycles: impact of progressive ring size reduction on synthesis and structure.Journal of the American Chemical Society · 2012Article
- Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactions.Journal of the American Chemical Society · 2011Article
- Contemporary strategies for peptide macrocyclization.Nature chemistry · 2011Review
- Probing the bioactive conformation of an archetypal natural product HDAC inhibitor with conformationally homogeneous triazole-modified cyclic tetrapeptides.Angewandte Chemie (International ed. in English) · 2009Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A would-be amide: A 1,4-disubstituted 1,2,3-triazole was used as a surrogate for a trans amide bond to create a library of 16 diastereomeric pseudotetrapeptides as beta-turn mimetics. High-resolution structural analysis indicated that these scaffolds adopt distinct, rigid, conformationally homogeneous beta-turn-like structures (see example), some of which bind somatostatin receptor subtypes selectively, and some of which show broad-spectrum activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.