ArticleMethods in molecular biology (Clifton, N.J.)2009
Transposon mutagenesis in mice.
Article in Methods in molecular biology (Clifton, N.J.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Establishment of an integrated automated embryonic manipulation system for producing genetically modified mice.Scientific reports · 2021Article
- Identification of cancer driver genes using Sleeping Beauty transposon mutagenesis.Cancer science · 2021Review
- The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes.Microbiology spectrum · 2015Review
- Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy.Translational research : the journal of laboratory and clinical medicine · 2013Review
- The Mammalian Phenotype Ontology as a unifying standard for experimental and high-throughput phenotyping data.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Modeling human neurodegenerative diseases in transgenic systems.Human genetics · 2012Review
- Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Article
- Global methylation in exposure biology and translational medical science.Environmental health perspectives · 2011Article
- Development of the piggyBac transposable system for Plasmodium berghei and its application for random mutagenesis in malaria parasites.BMC genomics · 2011Article
- Probing human cardiovascular congenital disease using transgenic mouse models.Progress in molecular biology and translational science · 2011Review
- Random mutagenesis of the mouse genome: a strategy for discovering gene function and the molecular basis of disease.American journal of physiology. Gastrointestinal and liver physiology · 2011Review
- Gene targeting in the rat: advances and opportunities.Trends in genetics : TIG · 2010Review
- Transposon transgenesis in Xenopus.Methods (San Diego, Calif.) · 2010Review
- Germline modification of domestic animals.Animal reproductionArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
Abstract
Understanding the functional landscape of the mammalian genome is the next big challenge of biomedical research. The completion of the first phases of the mouse and human genome projects, and expression analyses using microarray hybridization, generate critically important questions about the functional landscape and structure of the mammalian genome: how many genes, and of what type, are there; what kind of functional elements make up a properly functioning gene? One step in this process will be to create mutations in every identifiable mouse gene and analyze the resultant phenotypes. Transposons are being considered as tools to further initiatives to create a comprehensive resource of mutant mouse strains. Also, it may be possible to use transposons in true forward genetic screens in the mouse. The "Sleeping Beauty" (SB) transposon system is one such tool. Moreover, due to its tendency for local hopping, SB has been proposed as a method for regional saturation mutagenesis of the mouse genome. In this chapter, we review the tools and methods currently available to create mutant mice using in vivo, germline transposition in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.