ReviewClinical and experimental nephrology2009
Slit diaphragm dysfunction in proteinuric states: identification of novel therapeutic targets for nephrotic syndrome.
Review in Clinical and experimental nephrology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Changes in the immunohistochemical expression of nephrin protein in renal corpuscle of rats in response to sleep disturbance.Journal of molecular histology · 2025Article
- A zebrafish model of congenital nephrotic syndrome of the Finnish type.Frontiers in cell and developmental biology · 2022Article
- New insight into podocyte slit diaphragm, a therapeutic target of proteinuria.Clinical and experimental nephrology · 2020Review
- Repeated administration of alpha-galactosylceramide ameliorates experimental lupus nephritis in mice.Scientific reports · 2018Article
- The renoprotective effect of shichimotsukokato on hypertension-induced renal dysfunction in spontaneously hypertensive rats.Journal of natural medicines · 2016Article
- Renal Effects and Underlying Molecular Mechanisms of Long-Term Salt Content Diets in Spontaneously Hypertensive Rats.PloS one · 2015Article
- Homocysteine in renovascular complications: hydrogen sulfide is a modulator and plausible anaerobic ATP generator.Nitric oxide : biology and chemistry · 2014Review
- Therapeutic target for nephrotic syndrome: Identification of novel slit diaphragm associated molecules.World journal of nephrology · 2014Review
- Constitutional Nephrin Deficiency in Conditionally Immortalized Human Podocytes Induced Epithelial-Mesenchymal Transition, Supported by β-Catenin/NF-kappa B Activation: A Consequence of Cell Junction Impairment?International journal of nephrology · 2013Article
- Wtip- and gadd45a-interacting protein dendrin is not crucial for the development or maintenance of the glomerular filtration barrier.PloS one · 2013Article
- Microarray analyses of glucocorticoid and vitamin D3 target genes in differentiating cultured human podocytes.PloS one · 2013Article
- DNA methylation changes between relapse and remission of minimal change nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2012Article
- Nuclear hormone receptors in podocytes.Cell & bioscience · 2012Article
- Dysregulated nephrin in diabetic nephropathy of type 2 diabetes: a cross sectional study.PloS one · 2012Article
- Common variation in GPC5 is associated with acquired nephrotic syndrome.Nature genetics · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several recent studies have demonstrated that the slit diaphragm of the glomerular epithelial cell (podocyte) is the structure likely to be the principal barrier in the glomerular capillary wall. Nephrin identified as a gene product mutated in congenital nephrotic syndrome located at the outer leaflet of plasma membranes of the slit diaphragm. The anti-nephrin antibody is capable of inducing massive proteinuria, which indicates that nephrin is a key functional molecule in the slit diaphragm. Expression of nephrin was reduced in glomeruli of minimal change nephrotic syndrome. Some recent studies demonstrated that podocin, CD2-associated protein and NEPH1 are also functional molecules in the slit diaphragm, and their expressions are altered in membranous nephropathy and also in focal glomerulosclerosis. These observations suggested that the alteration of the molecular arrangement in the slit diaphragm is involved in the development of proteinuria in several kinds of glomerular diseases. Recent studies of our group have demonstrated that type 1 receptor-mediated angiotensin II action reduced the expression of the slit diaphragm-associated molecules and that type 1 receptor blockade ameliorated proteinuria by preventing the function of angiotensin II on the slit diaphragm. By the subtraction hybridization techniques using glomerular cDNA of normal and proteinuric rats, we detected that synaptic vesicle protein 2B and ephrin B1 are involved in the maintenance of the barrier function of the slit diaphragm.
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