Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
The effect of beta-blockers on the diagnostic accuracy of vasodilator pharmacologic SPECT myocardial perfusion imaging.
Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- The effect of beta blocker withdrawal on adenosine myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Trial
- Non-invasive assessment of coronary artery disease with CT coronary angiography and SPECT: a novel dose-saving fast-track algorithm.European journal of nuclear medicine and molecular imaging · 2010Trial
- Patient-centric performance and interpretation of positron emission tomography /computed tomography myocardial perfusion imaging: a clinical consensus statement of the European Association of Cardiovascular Imaging of the European Society of Cardiology.European heart journal. Imaging methods and practice · 2026Review
- Effect of Beta-Blocker Consumption on the Severity and Extension of Perfusion Defects in Dipyridamole Myocardial Perfusion Single-Photon Emission Computed Tomography.World journal of nuclear medicine · 2024Article
- Dynamic myocardial CT perfusion imaging-state of the art.European radiology · 2023Review
- Statin therapy improves survival in patients with severe pulmonary hypertension: a propensity score matching study.Heart and vessels · 2017Article
- Article
- Withholding or continuing beta-blocker treatment before dipyridamole myocardial perfusion imaging for the diagnosis of coronary artery disease? A randomized clinical trial.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2013Article
- CT-based myocardial perfusion imaging-practical considerations: acquisition, image analysis, interpretation, and challenges.Journal of cardiovascular translational research · 2011Review
- The significance of transient ischemic dilation in the setting of otherwise normal SPECT radionuclide myocardial perfusion images.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2011Article
- CT perfusion: ready for prime time.Current cardiology reports · 2011Review
- Quantitative and qualitative analysis and interpretation of CT perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2010Review
- Single photon emission computed tomography for the diagnosis of coronary artery disease: an evidence-based analysis.Ontario health technology assessment series · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effect of beta (beta) blockers on the accuracy, particularly the sensitivity, of vasodilator radionuclide myocardial perfusion imaging (MPI) is not entirely clear. This study aimed to further assess the effect of beta-blockers on the ability of MPI to identify significant and high-risk coronary artery disease (CAD). METHODS AND
resultsFor 555 patients who underwent vasodilator MPI and had coronary angiography within 90 days, global and per-vessel sensitivities and specificities were calculated, and were found to be similar between patients taking beta-blockers and those who were not. beta-blockers did not decrease the ability to detect patients with multivessel disease. Summed stress scores and summed rest scores were likewise similar in both groups. To account in part for catheterization referral bias and the potential of false-negative MPI studies in patients receiving beta-blockers, survival analysis was performed on 2646 patients with normal MPI studies who did not undergo cardiac catheterization and failed to demonstrate significant mortality difference related to the taking of beta-blockers.
conclusionsbeta-blocker therapy does not diminish the ability of vasodilator stress MPI to detect clinically significant CAD, nor hide the mortality risk of patients with normal studies not referred for catheterization.
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