ArticlePLoS genetics2009
Fate of the H-NS-repressed bgl operon in evolution of Escherichia coli.
Article in PLoS genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Challenging the fitness cost: expression of the cryptic E. coli bgl operon lacks a measurable growth disadvantage in exponential phase.Archives of microbiology · 2026Article
- The B. subtilis Rok protein is an atypical H-NS-like protein irresponsive to physico-chemical cues.Nucleic acids research · 2022Article
- Bacterial H-NS contacts DNA at the same irregularly spaced sites in both bridged and hemi-sequestered linear filaments.iScience · 2022Article
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- Hopping into a hot seat: Role of DNA structural features on IS5-mediated gene activation and inactivation under stress.PloS one · 2017Article
- Genomic characterisation of an endometrial pathogenic Escherichia coli strain reveals the acquisition of genetic elements associated with extra-intestinal pathogenicity.BMC genomics · 2014Article
- Article
- Article
- Activation of Escherichia coli antiterminator BglG requires its phosphorylation.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Mutations at several loci cause increased expression of ribonucleotide reductase in Escherichia coli.Journal of bacteriology · 2012Article
- H-NS mediates the dissociation of a refractory protein-DNA complex during Tn10/IS10 transposition.Nucleic acids research · 2011Article
- Insight into bacterial phosphotransferase system-mediated signaling by interspecies transplantation of a transcriptional regulator.Journal of bacteriology · 2011Article
- BglJ-RcsB heterodimers relieve repression of the Escherichia coli bgl operon by H-NS.Journal of bacteriology · 2010Article
- The GimA locus of extraintestinal pathogenic E. coli: does reductive evolution correlate with habitat and pathotype?PloS one · 2010Article
- Identification of protective and broadly conserved vaccine antigens from the genome of extraintestinal pathogenic Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Article
- Participation of regulator AscG of the beta-glucoside utilization operon in regulation of the propionate catabolism operon.Journal of bacteriology · 2009Article
- Characterization of a beta-glucoside operon (bgc) prevalent in septicemic and uropathogenic Escherichia coli strains.Applied and environmental microbiology · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the enterobacterial species Escherichia coli and Salmonella enterica, expression of horizontally acquired genes with a higher than average AT content is repressed by the nucleoid-associated protein H-NS. A classical example of an H-NS-repressed locus is the bgl (aryl-beta,D-glucoside) operon of E. coli. This locus is "cryptic," as no laboratory growth conditions are known to relieve repression of bgl by H-NS in E. coli K12. However, repression can be relieved by spontaneous mutations. Here, we investigated the phylogeny of the bgl operon. Typing of bgl in a representative collection of E. coli demonstrated that it evolved clonally and that it is present in strains of the phylogenetic groups A, B1, and B2, while it is presumably replaced by a cluster of ORFans in the phylogenetic group D. Interestingly, the bgl operon is mutated in 20% of the strains of phylogenetic groups A and B1, suggesting erosion of bgl in these groups. However, bgl is functional in almost all B2 isolates and, in approximately 50% of them, it is weakly expressed at laboratory growth conditions. Homologs of bgl genes exist in Klebsiella, Enterobacter, and Erwinia species and also in low GC-content Gram-positive bacteria, while absent in E. albertii and Salmonella sp. This suggests horizontal transfer of bgl genes to an ancestral Enterobacterium. Conservation and weak expression of bgl in isolates of phylogenetic group B2 may indicate a functional role of bgl in extraintestinal pathogenic E. coli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.