ArticlePLoS genetics2009
Uncoupling time and space in the collinear regulation of Hox genes.
Article in PLoS genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 98 citations in OpenAlex.
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- Human colon organoid differentiation from induced pluripotent stem cells using an improved method.FEBS letters · 2025Article
- Homeotic and nonhomeotic patterns in the tetrapod vertebral formula.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- CTCF-dependent insulation ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- HOXA9 transcription factor is a double-edged sword: from development to cancer progression.Cancer metastasis reviews · 2024Review
- Intrinsic and extrinsic cues time somite progenitor contribution to the vertebrate primary body axis.eLife · 2024Article
- Dynamic extrinsic pacing of the HOX clock in human axial progenitors controls motor neuron subtype specification.Development (Cambridge, England) · 2021Article
- Homeotic Genes: Clustering, Modularity, and Diversity.Frontiers in cell and developmental biology · 2021Review
- HOXA5 confers tamoxifen resistance via the PI3K/AKT signaling pathway in ER-positive breast cancer.Journal of Cancer · 2021Article
- Mammalian-specific ectodermal enhancers control the expression ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Geminin is required for Hox gene regulation to pattern the developing limb.Developmental biology · 2020Article
- Identification of lncRNAs Involved in PCV2 Infection of PK-15 Cells.Pathogens (Basel, Switzerland) · 2020Article
- Transcriptionally dynamic progenitor populations organised around a stable niche drive axial patterning.Development (Cambridge, England) · 2019Article
- Some Questions and Answers About the Role ofFrontiers in cell and developmental biology · 2019Article
- Abnormal Elongations of HOX Gene Clusters May Cause Cancer.Frontiers in cell and developmental biology · 2018Article
- Article
- Collinear Hox-Hox interactions are involved in patterning the vertebrate anteroposterior (A-P) axis.PloS one · 2017Article
- Intrinsic Noise Profoundly Alters the Dynamics and Steady State of Morphogen-Controlled Bistable Genetic Switches.PLoS computational biology · 2016Article
- Reorganisation of Hoxd regulatory landscapes during the evolution of a snake-like body plan.eLife · 2016Article
- Hoxa5: A Key Player in Development and Disease.Journal of developmental biology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During development of the vertebrate body axis, Hox genes are transcribed sequentially, in both time and space, following their relative positions within their genomic clusters. Analyses of animal genomes support the idea that Hox gene clustering is essential for coordinating the various times of gene activations. However, the eventual collinear ordering of the gene specific transcript domains in space does not always require genomic clustering. We analyzed these complex regulatory relationships by using mutant alleles at the mouse HoxD locus, including one that splits the cluster into two pieces. We show that both positive and negative regulatory influences, located on either side of the cluster, control an early phase of collinear expression in the trunk. Interestingly, this early phase does not systematically impact upon the subsequent expression patterns along the main body axis, indicating that the mechanism underlying temporal collinearity is distinct from those acting during the second phase. We discuss the potential functions and evolutionary origins of these mechanisms, as well as their relationship with similar processes at work during limb development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.