ArticleParasitology2009
Transcriptome analysis of Schistosoma mansoni larval development using serial analysis of gene expression (SAGE).
Article in Parasitology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Evaluation of Suitable Reference Gene During the Development of Paired or Unpaired FemalePathogens (Basel, Switzerland) · 2025Article
- A cercarial invadolysin interferes with the host immune response and facilitates infection establishment of Schistosoma mansoni.PLoS pathogens · 2023Article
- Comparative transcriptome profiles of Schistosoma japonicum larval stages: Implications for parasite biology and host invasion.PLoS neglected tropical diseases · 2022Article
- Assessment of reference genes at six different developmental stages of Schistosoma mansoni for quantitative RT-PCR.Scientific reports · 2021Article
- Modified PCR protocol to increase sensitivity for determination of bacterial community composition.Microbiome · 2021Article
- LncRNAs in molluscan and mammalian stages of parasitic schistosomes are developmentally-regulated and coordinately expressed with protein-coding genes.RNA biology · 2020Article
- Immune Evasion Strategies of Schistosomes.Frontiers in immunology · 2020Review
- Article
- Transcriptomic responses of Biomphalaria pfeifferi to Schistosoma mansoni: Investigation of a neglected African snail that supports more S. mansoni transmission than any other snail species.PLoS neglected tropical diseases · 2017Article
- Digital gene expression approach over multiple RNA-Seq data sets to detect neoblast transcriptional changes in Schmidtea mediterranea.BMC genomics · 2015Article
- Development of "-omics" research in Schistosoma spp. and -omics-based new diagnostic tools for schistosomiasis.Frontiers in microbiology · 2014Review
- Molluscan cells in culture: primary cell cultures and cell lines.Canadian journal of zoology · 2013Article
- Whole-organ isolation approach as a basis for tissue-specific analyses in Schistosoma mansoni.PLoS neglected tropical diseases · 2013Article
- Inferences on the biochemical and environmental regulation of universal stress proteins from Schistosomiasis parasites.Advances and applications in bioinformatics and chemistry : AABC · 2013Article
- Interaction of Schistosoma mansoni Sporocysts and Hemocytes of Biomphalaria.Journal of parasitology research · 2012Article
- Cloning and functional characterization of two calmodulin genes during larval development in the parasitic flatworm Schistosoma mansoni.The Journal of parasitology · 2011Article
- Developmental Regulation of Genes Encoding Universal Stress Proteins in Schistosoma mansoni.Gene regulation and systems biology · 2011Article
- Construction of a medicinal leech transcriptome database and its application to the identification of leech homologs of neural and innate immune genes.BMC genomics · 2010Article
- The identification of inhibitors of Schistosoma mansoni miracidial transformation by incorporating a medium-throughput small-molecule screen.Experimental parasitology · 2010Article
- Schistosomiasis in the People's Republic of China: the era of the Three Gorges Dam.Clinical microbiology reviews · 2010Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
summaryInfection of the snail, Biomphalaria glabrata, by the free-swimming miracidial stage of the human blood fluke, Schistosoma mansoni, and its subsequent development to the parasitic sporocyst stage is critical to establishment of viable infections and continued human transmission. We performed a genome-wide expression analysis of the S. mansoni miracidia and developing sporocyst using Long Serial Analysis of Gene Expression (LongSAGE). Five cDNA libraries were constructed from miracidia and in vitro cultured 6- and 20-day-old sporocysts maintained in sporocyst medium (SM) or in SM conditioned by previous cultivation with cells of the B. glabrata embryonic (Bge) cell line. We generated 21 440 SAGE tags and mapped 13 381 to the S. mansoni gene predictions (v4.0e) either by estimating theoretical 3' UTR lengths or using existing 3' EST sequence data. Overall, 432 transcripts were found to be differentially expressed amongst all 5 libraries. In total, 172 tags were differentially expressed between miracidia and 6-day conditioned sporocysts and 152 were differentially expressed between miracidia and 6-day unconditioned sporocysts. In addition, 53 and 45 tags, respectively, were differentially expressed in 6-day and 20-day cultured sporocysts, due to the effects of exposure to Bge cell-conditioned medium.
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