ArticleBMC microbiology2009
The outcome of Cryptococcus neoformans intracellular pathogenesis in human monocytes.
Article in BMC microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 45 citations in OpenAlex.
- Immune Modulation and Evasion byACS omega · 2026Review
- Pathogenicity and virulence of Cryptococcus neoformans from an environmental perspective.Virulence · 2025Review
- Assessing Phagocytosis of Cryptococcus neoformans Cells in Human Monocytes or the J774 Murine Macrophage Cell Line.Methods in molecular biology (Clifton, N.J.) · 2024Article
- A Systematic Review ofLife (Basel, Switzerland) · 2023Review
- The Diverse Roles of Monocytes in Cryptococcosis.Journal of fungi (Basel, Switzerland) · 2020Review
- Monocytes and the Host Response to Fungal Pathogens.Frontiers in cellular and infection microbiology · 2020Review
- Nonlytic exocytosis of Cryptococcus neoformans from neutrophils in the brain vasculature.Cell communication and signaling : CCS · 2019Article
- Inflammatory monocytes are detrimental to the host immune response during acute infection with Cryptococcus neoformans.PLoS pathogens · 2019Article
- Antibody Responses in HIV-Infected Patients With Advanced Immunosuppression and Asymptomatic Cryptococcal Antigenemia.Open forum infectious diseases · 2019Article
- Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection.Scientific reports · 2018Article
- Conservation of Intracellular Pathogenic Strategy among Distantly Related Cryptococcal Species.Infection and immunity · 2018Article
- Cutaneous Manifestations of Infections in Solid Organ Transplant Recipients.Current infectious disease reports · 2018Review
- Characterizing the Mechanisms of Nonopsonic Uptake of Cryptococci by Macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Innate Immune Responses toJournal of fungi (Basel, Switzerland) · 2017Article
- The Membrane Phospholipid Binding Protein Annexin A2 Promotes Phagocytosis and Nonlytic Exocytosis of Cryptococcus neoformans and Impacts Survival in Fungal Infection.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Virulence-Associated Enzymes of Cryptococcus neoformans.Eukaryotic cell · 2015Review
- Characterization of the virulence of Cryptococcus neoformans strains in an insect model.Virulence · 2015Article
- Article
- Temporal kinetics and quantitative analysis of Cryptococcus neoformans nonlytic exocytosis.Infection and immunity · 2014Article
- Cryptococcus neoformans: historical curiosity to modern pathogen.Yeast (Chichester, England) · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCryptococcus neoformans is an encapsulated yeast that is a facultative intracellular pathogen. The interaction between macrophages and C. neoformans is critical for extrapulmonary dissemination of this pathogenic yeast. C. neoformans can either lyse macrophages or escape from within them through a process known as phagosomal extrusion. However, most studies of intracellular pathogenesis have been made with mouse cells and their relevance to human infection is uncertain. In this study we extended studies of C. neoformans-macrophage cellular interaction/s to human peripheral blood monocytes.
resultsThis study demonstrated that C. neoformans can shed polysaccharide within human monocytes, spread from cell to cell, and be extruded from them. Furthermore, human monocytes responded to ingestion of C. neoformans with cell cycle progression from G1 to S.
conclusionSimilarities between mouse and human cells support the suitability of mouse cells for the study of intracellular pathogenesis mechanisms. Given that these hosts diverged over 70 million years ago, the similar pathogenic strategies for C. neoformans in murine and human cells supports the hypothesis that the mechanism that underlies the mammalian intracellular pathogenesis of C. neoformans originated from interactions with a third host, possibly soil amoeboid predators, before the mammalian radiation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.