ArticleBMC microbiology2009
Comparative genomics of lactic acid bacteria reveals a niche-specific gene set.
Article in BMC microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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61 citing papers in PubMed.
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- Complete genome sequence and genomic characterization of the probioticOpen veterinary journal · 2025Review
- Genomic insights into habitat adaptation of Lactobacillus species.World journal of microbiology & biotechnology · 2025Article
- Characterization of Probiotic Properties and Whole-Genome Analysis ofMicroorganisms · 2024Article
- Bioinformatics and its role in the study of the evolution and probiotic potential of lactic acid bacteria.Food science and biotechnology · 2023Review
- Subspecies-level genome comparison of Lactobacillus delbrueckii.Scientific reports · 2023Article
- In Silico Evidence of the Multifunctional Features ofFoods (Basel, Switzerland) · 2023Article
- Understanding the transcriptomic response ofFrontiers in microbiology · 2023Article
- Homologous genes shared between probiotics and pathogens affect the adhesion of probiotics and exclusion of pathogens in the gut mucus of shrimp.Frontiers in microbiology · 2023Article
- Comprehensive genomic analysis of hypocholesterolemic probioticFrontiers in nutrition · 2023Article
- Potential of dietary hemp and cannabinoids to modulate immune response to enhance health and performance in animals: opportunities and challenges.Frontiers in immunology · 2023Review
- Metabolomic Analysis ofFrontiers in microbiology · 2022Article
- Plasmids encode niche-specific traits inMicrobial genomics · 2021Article
- Article
- Prebiotics Inulin Metabolism by Lactic Acid Bacteria From Young Rabbits.Frontiers in veterinary science · 2021Article
- Functional characterization and immunomodulatory properties of Lactobacillus helveticus strains isolated from Italian hard cheeses.PloS one · 2021Article
- Isolation and characterisation of novel phages infecting Lactobacillus plantarum and proposal of a new genus, "Silenusvirus".Scientific reports · 2020Article
1 more citing papers are in PubMed but not listed here.
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe recently sequenced genome of Lactobacillus helveticus DPC4571 revealed a dairy organism with significant homology (75% of genes are homologous) to a probiotic bacteria Lb. acidophilus NCFM. This led us to hypothesise that a group of genes could be determined which could define an organism's niche.
resultsTaking 11 fully sequenced lactic acid bacteria (LAB) as our target, (3 dairy LAB, 5 gut LAB and 3 multi-niche LAB), we demonstrated that the presence or absence of certain genes involved in sugar metabolism, the proteolytic system, and restriction modification enzymes were pivotal in suggesting the niche of a strain. We identified 9 niche specific genes, of which 6 are dairy specific and 3 are gut specific. The dairy specific genes identified in Lactobacillus helveticus DPC4571 were lhv_1161 and lhv_1171, encoding components of the proteolytic system, lhv_1031 lhv_1152, lhv_1978 and lhv_0028 encoding restriction endonuclease genes, while bile salt hydrolase genes lba_0892 and lba_1078, and the sugar metabolism gene lba_1689 from Lb. acidophilus NCFM were identified as gut specific genes.
conclusionComparative analysis revealed that if an organism had homologs to the dairy specific geneset, it probably came from a dairy environment, whilst if it had homologs to gut specific genes, it was highly likely to be of intestinal origin.We propose that this "barcode" of 9 genes will be a useful initial guide to researchers in the LAB field to indicate an organism's ability to occupy a specific niche.
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