Evidence map›Paper›PMID 19265501›Full record

ArticleThyroid : official journal of the American Thyroid Association2009

Ectopic thymus presenting as a thyroid nodule in a patient with the Carney complex.

Nickolas Courcoutsakis, Nickolas Patronas, Armando C Filie, J Aidan Carney, Andreas Moraitis, Constantine A Stratakis

Abstract readCase Reports
In one paragraph

Article in Thyroid : official journal of the American Thyroid Association, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Nickolas CourcoutsakisSection on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
Nickolas Patronas
Armando C Filie
J Aidan Carney
Andreas Moraitis
Constantine A Stratakis
National Institutes of Health · USMayo Clinic · USNational Cancer Institute · US

Funding

Cytopathology CoreZICBC011052 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI FILIE, ARMANDO · 2009 to 2025
$30.8M
Molecular Genetics Of Adrenocortical Tumors And Related DisordersZIAHD000642 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STRATAKIS, CONSTANTINE A. · 2009 to 2011
$9.6M
Molecular Genetics Of Adrenocortical Tumors And Related DisordersZ01HD000642 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STRATAKIS, CONSTANTINE A. · 1998 to 2008
$4.7M
Intramural NIH HHSNICHD NIH HHS Z01-HD-000642-04
6 · The paper itself

Abstract

Ectopic thymic tissue within the thyroid gland is rare. Patients with a complex of myxomas, spotty skin pigmentation, and endocrine overactivity, collectively known as Carney complex (CNC), have a predisposition towards the development of thyroid abnormalities, but there are no reports of thymic defects in CNC. We present the case of a 12-year-old boy with CNC and a growing thyroid nodule. The patient had the c.682 C > T (Arg228X) pathogenic PRKAR1A mutation. Hemithyroidectomy for a Hürthle cell adenoma led to the confirmation of distinct intrathyroidal ectopic thymic tissue. Thymic abnormalities have not been previously reported in CNC.

Indexed as

Adenoma, OxyphilicChildChoristomaCyclic AMP-Dependent Protein Kinase RIalpha SubunitDiagnosis, DifferentialDNAHumansIn Situ Hybridization, FluorescenceLentigoMaleMultiple Endocrine NeoplasiaPigmentation DisordersSyndromeThymus GlandThyroidectomyThyroid NoduleCyclic AMP-Dependent Protein Kinase RIalpha SubunitDNAPRKAR1A protein, human

Identifiers

PMID19265501
PMCPMC2962859
OpenAlexW1984282963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.