ArticleJournal of immunology (Baltimore, Md. : 1950)2009
Decreased NK cell frequency and function is associated with increased risk of KIR3DL allele polymorphism in simian immunodeficiency virus-infected rhesus macaques with high viral loads.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 51 citations in OpenAlex.
- Post-translational modification of NK cell receptors offers clues to antigenic specificity riddle.Frontiers in immunology · 2025Review
- NK cells modulate in vivo control of SARS-CoV-2 replication and suppression of lung damage.PLoS pathogens · 2024Article
- Natural Killer Cells Regulate Acute SIV Replication, Dissemination, and Inflammation, but Do Not Impact Independent Transmission Events.Journal of virology · 2023Article
- Review
- Elevated Natural Killer Cell-Mediated Cytotoxicity Is Associated with Cavity Formation in Pulmonary Tuberculosis Patients.Journal of immunology research · 2021Observational
- Nomenclature report for killer-cell immunoglobulin-like receptors (KIR) in macaque species: new genes/alleles, renaming recombinant entities and IPD-NHKIR updates.Immunogenetics · 2020Review
- Adaptive features of innate immune cells and their relevance to graft rejection.Current opinion in organ transplantation · 2019Review
- CMV Primes Functional Alternative Signaling in Adaptive Δg NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques.Cell reports · 2018Article
- Nomenclature for the KIR of non-human species.Immunogenetics · 2018Article
- Extensive Alternative Splicing of KIR Transcripts.Frontiers in immunology · 2018Article
- Redefining Memory: Building the Case for Adaptive NK Cells.Journal of virology · 2017Review
- Memory responses of natural killer cells.Seminars in immunology · 2017Review
- SIV-induced Translocation of Bacterial Products in the Liver Mobilizes Myeloid Dendritic and Natural Killer Cells Associated With Liver Damage.The Journal of infectious diseases · 2016Article
- Natural Killer Cell Memory.Immunity · 2015Review
- Antigen-specific NK cell memory in rhesus macaques.Nature immunology · 2015Article
- Suppression of a Natural Killer Cell Response by Simian Immunodeficiency Virus Peptides.PLoS pathogens · 2015Article
- The killer-cell immunoglobulin-like receptors of macaques.Immunological reviews · 2015Review
- Article
- MHC and KIR Polymorphisms in Rhesus Macaque SIV Infection.Frontiers in immunology · 2015Review
- Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection.PLoS pathogens · 2014Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
NK cells have been established as an important effector of innate immunity in a variety of viral infections. In HIV-1 infection in humans, alterations of NK cell function, frequency, and expression of various NK receptors have been reported to be associated with differential dynamics of disease progression. Expression of certain alleles of KIR3DL and KIR3DS receptors on NK cells was shown to correlate with levels of virus replication. In the SIV-infected rhesus macaque (RM) model of AIDS, several families of killer inhibitory Ig-related receptors (KIR receptors) corresponding to their human counterparts have been characterized, but only at the level of individual sequence variants. Here we define 14 different alleles of KIR3DL expressed among 38 SIV-infected RM, characterized by either high or low levels of SIV replication, by analyzing multiple sequences from individual animals and show an unequal distribution of certain alleles in these cohorts. High levels of SIV replication were associated with significant increases in KIR3DL mRNA levels in addition to decreases in both the frequency and function of NK cells in these animals. The higher frequency of inheritance of two KIR3DL alleles characterized by a single nucleotide polymorphism 159 H/Q was associated with RM that exhibited high plasma viral load. This data for the first time defines multiple alleles of KIR3DL in RM and shows an association between virus control, NK cell function and genetic polymorphisms of KIR receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.