ArticleJournal of immunology (Baltimore, Md. : 1950)2009
Evolution and survival of marine carnivores did not require a diversity of killer cell Ig-like receptors or Ly49 NK cell receptors.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 57 citations in OpenAlex.
- Diagnosis of canine B-cell chronic lymphoid leukemia with a CD21 negative phenotype using the LT21 clone CD21 antibody in flow cytometry: a case report.BMC veterinary research · 2024Article
- Comparative genomics of the Natural Killer Complex in carnivores.Frontiers in immunology · 2024Article
- Missing a "Missing Self" Mechanism: Modeling and Detection of Ly49 Expression in Canine NK Cells.ImmunoHorizons · 2023Article
- Understanding the evolution of immune genes in jawed vertebrates.Journal of evolutionary biology · 2023Review
- Comparative genomics of the Leukocyte Receptor Complex in carnivores.Frontiers in immunology · 2023Article
- Placing human gene families into their evolutionary context.Human genomics · 2022Review
- Immunoglobulin-like receptors and the generation of innate immune memory.Immunogenetics · 2022Review
- Single-cell transcriptomics of the naked mole-rat reveals unexpected features of mammalian immunity.PLoS biology · 2019Article
- Characterization and Potential Applications of Dog Natural Killer Cells in Cancer Immunotherapy.Journal of clinical medicine · 2019Review
- Unraveling the LRC Evolution in Mammals: IGSF1 and A1BG Provide the Keys.Genome biology and evolution · 2019Article
- Transcriptional Profiles of California Sea Lion Peripheral NK and CDFrontiers in immunology · 2019Article
- The Structure, Evolution, and Gene Expression Within the Caprine Leukocyte Receptor Complex.Frontiers in immunology · 2019Article
- The unique evolution of the pig LRC, a single KIR but expansion of LILR and a novel Ig receptor family.Immunogenetics · 2018Article
- Identification of novel polymorphisms and two distinct haplotype structures in dog leukocyte antigen class I genes: DLA-88, DLA-12 and DLA-64.Immunogenetics · 2018Article
- The evolution of the natural killer complex; a comparison between mammals using new high-quality genome assemblies and targeted annotation.Immunogenetics · 2017Article
- The evolution of natural killer cell receptors.Immunogenetics · 2016Review
- Cattle NK Cell Heterogeneity and the Influence of MHC Class I.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Co-evolution of MHC class I and variable NK cell receptors in placental mammals.Immunological reviews · 2015Review
- Definition of the cattle killer cell Ig-like receptor gene family: comparison with aurochs and human counterparts.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Isolation and characterization of canine natural killer cells.Veterinary immunology and immunopathology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Ly49 lectin-like receptors and killer cell Ig-like receptors (KIR) are structurally unrelated cell surface glycoproteins that evolved independently to function as diverse NK cell receptors for MHC class I molecules. Comparison of primates and various domesticated animals has shown that species have either a diverse Ly49 or KIR gene family, but not both. In four pinniped species of wild marine carnivore, three seals and one sea lion, we find that Ly49 and KIR are each represented by single, orthologous genes that exhibit little polymorphism and are transcribed to express cell surface protein. Pinnipeds are therefore species in which neither Ly49 nor KIR are polygenic, but retain the ancestral single-copy state. Whereas pinniped Ly49 has been subject to purifying selection, we find evidence for positive selection on KIR3DL during pinniped evolution. This selection, which focused on the D0 domain and the stem, points to the functionality of the KIR and most likely led to the sea lion's loss of D0. In contrast to the dynamic and rapid evolution of the KIR and Ly49 genes in other species, the pinniped KIR and Ly49 have been remarkably stable during the >33 million years since the last common ancestor of seals and sea lions. These results demonstrate that long-term survival of placental mammal species need not require a diverse system of either Ly49 or KIR NK cell receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.