ArticleDiabetes2009
Short-term exercise training does not stimulate skeletal muscle ATP synthesis in relatives of humans with type 2 diabetes.
Article in Diabetes, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 74 citations in OpenAlex.
- Determinants of the postprandial triglyceride response to a high-fat meal in healthy overweight and obese adults.Lipids in health and disease · 2021Trial
- A single nucleotide polymorphism associates with the response of muscle ATP synthesis to long-term exercise training in relatives of type 2 diabetic humans.Diabetes care · 2012Trial
- Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus.American journal of physiology. Endocrinology and metabolism · 2009Trial
- Exercise Resistance in Obese Male NZO Mice Manifests as Local Muscle Remodelling Without Glycaemic Improvements.Diabetes, obesity & metabolism · 2026Article
- Intra-Individual Variations in How Insulin Sensitivity Responds to Long-Term Exercise: Predictions by Machine Learning Based on Large-Scale Serum Proteomics.Metabolites · 2024Article
- Nonequilibrium thermodynamics and mitochondrial protein content predict insulin sensitivity and fuel selection during exercise in human skeletal muscle.Frontiers in physiology · 2023Article
- Article
- Physical Fitness and Cardiovascular Risk Factors in Novel Diabetes Subgroups.The Journal of clinical endocrinology and metabolism · 2022Article
- Posttranscriptional Regulation of Insulin Resistance: Implications for Metabolic Diseases.Biomolecules · 2022Review
- Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males.Science advances · 2021Article
- New Insights Into Mitochondrial Dysfunction at Disease Susceptibility Loci in the Development of Type 2 Diabetes.Frontiers in endocrinology · 2021Article
- Observational
- Combined culture experiment of mouse bone marrow mesenchymal stem cells and bioceramic scaffolds.Experimental and therapeutic medicine · 2020Article
- The integrative biology of type 2 diabetes.Nature · 2019Review
- Adenosine Triphosphate Production of Muscle Mitochondria after Acute Exercise in Lean and Obese Humans.Medicine and science in sports and exercise · 2019Article
- Mitochondrial ATP synthase β-subunit production rate and ATP synthase specific activity are reduced in skeletal muscle of humans with obesity.Experimental physiology · 2019Article
- Review
- Cohort profile: the German Diabetes Study (GDS).Cardiovascular diabetology · 2016Article
- Insulin Resistance in Human iPS Cells Reduces Mitochondrial Size and Function.Scientific reports · 2016Article
- Less pronounced response to exercise in healthy relatives to type 2 diabetic subjects compared with controls.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe tested the hypothesis that short-term exercise training improves hereditary insulin resistance by stimulating ATP synthesis and investigated associations with gene polymorphisms. RESEARCH DESIGN AND
methodsWe studied 24 nonobese first-degree relatives of type 2 diabetic patients and 12 control subjects at rest and 48 h after three bouts of exercise. In addition to measurements of oxygen uptake and insulin sensitivity (oral glucose tolerance test), ectopic lipids and mitochondrial ATP synthesis were assessed using(1)H and(31)P magnetic resonance spectroscopy, respectively. They were genotyped for polymorphisms in genes regulating mitochondrial function, PPARGC1A (rs8192678) and NDUFB6 (rs540467).
resultsRelatives had slightly lower (P = 0.012) insulin sensitivity than control subjects. In control subjects, ATP synthase flux rose by 18% (P = 0.0001), being 23% higher (P = 0.002) than that in relatives after exercise training. Relatives responding to exercise training with increased ATP synthesis (+19%, P = 0.009) showed improved insulin sensitivity (P = 0.009) compared with those whose insulin sensitivity did not improve. A polymorphism in the NDUFB6 gene from respiratory chain complex I related to ATP synthesis (P = 0.02) and insulin sensitivity response to exercise training (P = 0.05). ATP synthase flux correlated with O(2)uptake and insulin sensitivity.
conclusionsThe ability of short-term exercise to stimulate ATP production distinguished individuals with improved insulin sensitivity from those whose insulin sensitivity did not improve. In addition, the NDUFB6 gene polymorphism appeared to modulate this adaptation. This finding suggests that genes involved in mitochondrial function contribute to the response of ATP synthesis to exercise training.
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