Trial reportAmerican journal of respiratory and critical care medicine2009
Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.
Trial report in American journal of respiratory and critical care medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: a meta-analysis based on 24 publications.BMC medical genetics · 2020Pooled it
- Identification of ATPAF1 as a novel candidate gene for asthma in children.The Journal of allergy and clinical immunology · 2011Trial
- The interaction of glutathione S-transferase M1-null variants with tobacco smoke exposure and the development of childhood asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2009Trial
- Genome-wide association study of atopic and autoimmune comorbidities in alopecia areata.Frontiers in immunology · 2026Article
- High expression of ITGB3 ameliorates asthma by inhibiting epithelial-mesenchymal transformation through suppressing the activation of NF-kB pathway.Scientific reports · 2025Article
- Asthma Susceptibility GeneAmerican journal of respiratory cell and molecular biology · 2022Article
- A cis-eQTL allele regulating reduced expression of CHI3L1 is associated with late-onset adult asthma in Japanese cohorts.BMC medical genetics · 2019Article
- Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites.Nature communications · 2015Article
- The Association of GSDMB and ORMDL3 Gene Polymorphisms With Asthma: A Meta-Analysis.Allergy, asthma & immunology research · 2015Article
- Article
- Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study.The Journal of allergy and clinical immunology · 2014Article
- Epistatic effects of multiple receptor genes on pathophysiology of asthma - its limits and potential for clinical application.Medical science monitor : international medical journal of experimental and clinical research · 2014Review
- SOCS3 dictates the transition of divergent time-phased events in granulocyte TNF-α signaling.Cellular & molecular immunology · 2014Article
- Investigating highly replicated asthma genes as candidate genes for allergic rhinitis.BMC medical genetics · 2013Article
- Copy number variation genotyping using family information.BMC bioinformatics · 2013Article
- In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH(2)) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator.Pulmonary pharmacology & therapeutics · 2013Article
- Copy number variation prevalence in known asthma genes and their impact on asthma susceptibility.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2013Article
- Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes.The Journal of allergy and clinical immunology · 2013Article
- Poor reproducibility of allergic rhinitis SNP associations.PloS one · 2013Article
- Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleAssociation studies have implicated many genes in asthma pathogenesis, with replicated associations between single-nucleotide polymorphisms (SNPs) and asthma reported for more than 30 genes. Genome-wide genotyping enables simultaneous evaluation of most of this variation, and facilitates more comprehensive analysis of other common genetic variation around these candidate genes for association with asthma.
objectivesTo use available genome-wide genotypic data to assess the reproducibility of previously reported associations with asthma and to evaluate the contribution of additional common genetic variation surrounding these loci to asthma susceptibility.
methodsIllumina Human Hap 550Kv3 BeadChip (Illumina, San Diego, CA) SNP arrays were genotyped in 422 nuclear families participating in the Childhood Asthma Management Program. Genes with at least one SNP demonstrating prior association with asthma in two or more populations were tested for evidence of association with asthma, using family-based association testing. MEASUREMENTS AND MAIN
resultsWe identified 39 candidate genes from the literature, using prespecified criteria. Of the 160 SNPs previously genotyped in these 39 genes, 10 SNPs in 6 genes were significantly associated with asthma (including the first independent replication for asthma-associated integrin beta(3) [ITGB3]). Evaluation of 619 additional common variants included in the Illumina 550K array revealed additional evidence of asthma association for 15 genes, although none were significant after adjustment for multiple comparisons.
conclusionsWe replicated asthma associations for a minority of candidate genes. Pooling genome-wide association study results from multiple studies will increase the power to appreciate marginal effects of genes and further clarify which candidates are true "asthma genes."
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.