ArticleThe American journal of pathology2009
Ultraviolet A within sunlight induces mutations in the epidermal basal layer of engineered human skin.
Article in The American journal of pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Insights from dual-platform metabolomics on durian flowers: An alternative source of procyanidins from agricultural waste with bioactivities.Food chemistry: X · 2025Article
- Engineering a Multilayered Skin Equivalent: The Importance of Endogenous Extracellular Matrix and Model Flexibility for Nuanced and Accurate Skin Studies.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Comparison of photodamage in non-pigmented and pigmented human skin equivalents exposed to repeated ultraviolet radiation to investigate the role of melanocytes in skin photoprotection.Frontiers in medicine · 2024Article
- The Damaging Effects of Long UVA (UVA1) Rays: A Major Challenge to Preserve Skin Health and Integrity.International journal of molecular sciences · 2022Review
- The Influence of UV Radiation on the Degradation of Pharmaceutical Formulations Containing Quercetin.Molecules (Basel, Switzerland) · 2020Article
- Article
- Photostability of Topical Agents Applied to the Skin: A Review.Pharmaceutics · 2019Review
- Targeting G-quadruplexes with Organic Dyes: Chelerythrine-DNA Binding Elucidated by Combining Molecular Modeling and Optical Spectroscopy.Antioxidants (Basel, Switzerland) · 2019Article
- The effects of phototherapy and melanocytes on keratinocytes.Experimental and therapeutic medicine · 2018Article
- A role for human mitochondrial complex II in the production of reactive oxygen species in human skin.Redox biology · 2014Article
- Diversity of biological effects induced by longwave UVA rays (UVA1) in reconstructed skin.PloS one · 2014Article
- Tretinoin photostability: comparison of micronized tretinoin gel 0.05% and tretinoin gel 0.025% following exposure to fluorescent and solar light.The Journal of clinical and aesthetic dermatology · 2013Article
- Effects of cigarette smoke extracts on the growth and senescence of skin fibroblasts in vitro.International journal of biological sciences · 2013Article
- UVA irradiation of dysplastic keratinocytes: oxidative damage versus antioxidant defense.International journal of molecular sciences · 2012Article
- Cutaneous responses to environmental stressors.Annals of the New York Academy of Sciences · 2012Review
- Resveratrol-sensitized UVA induced apoptosis in human keratinocytes through mitochondrial oxidative stress and pore opening.Journal of photochemistry and photobiology. B, Biology · 2012Article
- Activation of p38 MAP kinase and JNK pathways by UVA irradiation.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2012Article
- Tretinoin photostability: comparison of micronized tretinoin (0.05%) gel and tretinoin (0.025%) gel following exposure to ultraviolet a light.The Journal of clinical and aesthetic dermatology · 2012Article
- The immune-modulating cytokine and endogenous Alarmin interleukin-33 is upregulated in skin exposed to inflammatory UVB radiation.The American journal of pathology · 2011Article
- UV signature mutations.Photochemistry and photobiologyReview
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ultraviolet B (UVB) waveband within sunlight is an important carcinogen; however, UVA is also likely to be involved. By ascribing mutations to being either UVB or UVA induced, we have previously shown that human skin cancers contain similar numbers of UVB- and UVA-induced mutations, and, importantly, the UVA mutations were at the base of the epidermis of the tumors. To determine whether these mutations occurred in response to UV, we exposed engineered human skin (EHS) to UVA, UVB, or a mixture that resembled sunlight, and then detected mutations by both denaturing high-performance liquid chromatography and DNA sequencing. EHS resembles human skin, modeling differential waveband penetration to the basal, dividing keratinocytes. We administered only four low doses of UV exposure. Both UVA and UVB induced p53 mutations in irradiated EHS, suggesting that sunlight doses that are achievable during normal daily activities are mutagenic. UVA- but not UVB-induced mutations predominated in the basal epidermis that contains dividing keratinocytes and are thought to give rise to skin tumors. These studies indicate that both UVA and UVB at physiological doses are mutagenic to keratinocytes in EHS.
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