ReviewClinical chemistry2009
Metagenomic pyrosequencing and microbial identification.
Review in Clinical chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 174 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
174 citing papers in PubMed.
- The Human Microbiome Project strategy for comprehensive sampling of the human microbiome and why it matters.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Trial
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- The Incredible Potential of Cave Actinobacteria in Finding New Antimicrobials and Bioactive Compounds.Chemistry & biodiversity · 2026Review
- Article
- Exploiting fuzzy weights in CNN model-based taxonomic classification of 500-bp sequence bacterial dataset.Scientific reports · 2025Article
- Bacterial community profile of three Ethiopian hot springs based on 16S rRNA gene nanopore sequencing.Scientific reports · 2025Article
- Celiac disease and human gut microbiota - how can we study the composition of microorganisms?Przeglad gastroenterologiczny · 2025Review
- The Influence of Microbiota on Wild Birds' Parental Coprophagy Behavior: Current Advances and Future Research Directions.Microorganisms · 2024Review
- Characterization of the Blood Bacterial Microbiota in Lowland Tapirs (Microorganisms · 2024Article
- Article
- Advancing quantitative PCR with color cycle multiplex amplification.Nucleic acids research · 2024Article
- Human gastric microbiota analysis of refractory H. pylori infection.Scientific reports · 2024Article
- Immunological and molecular diagnostic techniques in fish health: present and future prospectus.Molecular biology reports · 2024Review
- Application of photoelectrochemical oxidation of wastewater used in the cooling tower water and its influence on microbial corrosion.Frontiers in microbiology · 2024Article
- The changes of intestinal flora and metabolites in atopic dermatitis mice.Frontiers in microbiology · 2024Article
- Developing diagnostic tools for canine periodontitis: combining molecular techniques and machine learning models.BMC veterinary research · 2023Article
- Bacterial Communities in Effluents Rich in Phenol and Their Potential in Bioremediation: Kinetic Modeling.International journal of environmental research and public health · 2022Article
- Bacterial Compositional Shifts of Gut Microbiomes in Patients with Rheumatoid Arthritis in Association with Disease Activity.Microorganisms · 2022Article
- The role of gut microbiome in inflammatory skin disorders: A systematic review.Dermatology reports · 2022Article
- Diagnosis of Viral Diseases Using Deep Sequencing and Metagenomics Analyses.Methods in molecular biology (Clifton, N.J.) · 2022Article
114 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundThe Human Microbiome Project has ushered in a new era for human metagenomics and high-throughput next-generation sequencing strategies. CONTENT: This review describes evolving strategies in metagenomics, with a special emphasis on the core technology of DNA pyrosequencing. The challenges of microbial identification in the context of microbial populations are discussed. The development of next-generation pyrosequencing strategies and the technical hurdles confronting these methodologies are addressed. Bioinformatics-related topics include taxonomic systems, sequence databases, sequence-alignment tools, and classifiers. DNA sequencing based on 16S rRNA genes or entire genomes is summarized with respect to potential pyrosequencing applications. SUMMARY: Both the approach of 16S rDNA amplicon sequencing and the whole-genome sequencing approach may be useful for human metagenomics, and numerous bioinformatics tools are being deployed to tackle such vast amounts of microbiological sequence diversity. Metagenomics, or genetic studies of microbial communities, may ultimately contribute to a more comprehensive understanding of human health, disease susceptibilities, and the pathophysiology of infectious and immune-mediated diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.