ReviewCurrent opinion in immunology2009
The diversity of costimulatory and inhibitory receptor pathways and the regulation of antiviral T cell responses.
Review in Current opinion in immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 141 citations in OpenAlex.
- Trial
- Taming interleukin-12: Engineering of bispecific antibody-based IL-12 mimetics with biased agonism capacities.Protein science : a publication of the Protein Society · 2025Article
- A research protocol for a prospective, multicenter, cohort study on interferon therapy for chronic hepatitis B combined with metabolism-associated fatty liver disease to achieve clinical cure.Frontiers in public health · 2025Article
- Myeloid-Derived Suppressor Cells Induce Exhaustion-Like CD8International journal of biological sciences · 2024Article
- Dysfunction and regulatory interplay of T and B cells in chronic hepatitis B: immunotherapy and emerging antiviral strategies.Frontiers in cellular and infection microbiology · 2024Review
- The role of CD4MedComm · 2023Review
- Lymphocyte activation gene 3 is increased and affects cytokine production in rheumatoid arthritis.Arthritis research & therapy · 2023Article
- The current state and future of T-cell exhaustion research.Oxford open immunology · 2023Review
- Exploring the immune microenvironment of osteosarcoma through T cell exhaustion-associated gene expression: a study on prognosis prediction.Frontiers in immunology · 2023Article
- Implications and Emerging Therapeutic Avenues of Inflammatory Response in HPV+ Head and Neck Squamous Cell Carcinoma.Cancers · 2022Review
- Clinical and prognostic implications of an immune-related risk model based on TP53 status in lung adenocarcinoma.Journal of cellular and molecular medicine · 2022Article
- The roadmap towards cure of chronic hepatitis B virus infection.Journal of the Royal Society of New Zealand · 2022Review
- Inhibitory Immune Checkpoint Receptors and Ligands as Prognostic Biomarkers in COVID-19 Patients.Frontiers in immunology · 2022Review
- LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy.The Journal of experimental medicine · 2021Article
- Not-so-opposite ends of the spectrum: CD8Nature immunology · 2021Review
- A proportion of CD4+ T cells from patients with chronic Chagas disease undergo a dysfunctional process, which is partially reversed by benznidazole treatment.PLoS neglected tropical diseases · 2021Article
- Transcriptional regulatory network for the establishment of CD8Experimental & molecular medicine · 2021Review
- Platelet Induced Functional Alteration of CD4International journal of molecular sciences · 2020Article
- Exosomes Represent an Immune Suppressive T Cell Checkpoint in Human Chronic Inflammatory Microenvironments.Immunological investigations · 2020Article
- ThymicPeptides Reverse Immune Exhaustion in Patients with Reactivated Human Alphaherpesvirus1 Infections.International journal of molecular sciences · 2020Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
T cell responses are regulated by integrating positive and negative signals from costimulatory and inhibitory receptors. While the function of specific T cell costimulatory molecules during infections has been appreciated for some time, recent observations have now revealed a crucial role for inhibitory receptors in regulating T cell responses to pathogens, especially during chronic infections. A key emerging principle is that there is considerable diversity in the number and type of inhibitory receptors that can be expressed by T cells during both acute and chronic infections. These distinct inhibitory pathways appear to cooperate in regulating T cell function, could have distinct mechanisms of action, and are likely to provide novel therapeutic targets during persisting infections and other diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.