ArticleVirology2009
Peripheral dendritic cells are essential for both the innate and adaptive antiviral immune responses in the central nervous system.
Article in Virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Viral immunological complications in neurological surgery: A comprehensive review of homeostatic disturbances and cognitive impairments.Surgical neurology international · 2025Review
- Neuroprotective Potential of Dendritic Cells and Sirtuins in Multiple Sclerosis.International journal of molecular sciences · 2022Review
- Article
- Dendritic Cell Vaccination of Glioblastoma: Road to Success or Dead End.Frontiers in immunology · 2021Review
- Conditional Silencing of H-2DJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis.Cell reports · 2018Article
- Controllable and uncontrollable stress differentially impact pathogenicity and survival in a mouse model of viral encephalitis.Journal of neuroimmunology · 2018Article
- Role of peripheral immune response in microglia activation and regulation of brain chemokine and proinflammatory cytokine responses induced during VSV encephalitis.Journal of neuroimmunology · 2014Article
- Sleep and behavior during vesicular stomatitis virus induced encephalitis in BALB/cJ and C57BL/6J mice.Brain, behavior, and immunity · 2014Article
- Adaptive immune response to viral infections in the central nervous system.Handbook of clinical neurology · 2014Article
- Metastatic melanoma to the brain: surgery and radiation is still the standard of care.Current treatment options in oncology · 2013Article
- IL-1R1 is required for dendritic cell-mediated T cell reactivation within the CNS during West Nile virus encephalitis.The Journal of experimental medicine · 2013Article
- Brain dendritic cells: biology and pathology.Acta neuropathologica · 2012Review
- Profound depletion of host conventional dendritic cells, plasmacytoid dendritic cells, and B cells does not prevent graft-versus-host disease induction.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Mechanisms of dendritic cell trafficking across the blood-brain barrier.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Review
- Innate-adaptive crosstalk: how dendritic cells shape immune responses in the CNS.Advances in experimental medicine and biology · 2012Review
- Heat-shock protein 70-dependent dendritic cell activation by 5-aminolevulinic acid-mediated photodynamic treatment of human glioblastoma spheroids in vitro.British journal of cancer · 2011Article
- Influence of enriched environment on viral encephalitis outcomes: behavioral and neuropathological changes in albino Swiss mice.PloS one · 2011Article
- MHC class I modulates NMDA receptor function and AMPA receptor trafficking.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS.Journal of neuroimmunology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Intranasal application of vesicular stomatitis virus (VSV) causes acute infection of the central nervous system (CNS). However, VSV encephalitis is not invariably fatal, suggesting that the CNS may contain a professional antigen-presenting cell (APC) capable of inducing or propagating a protective antiviral immune response. To examine this possibility, we first characterized the cellular elements that infiltrate the brain as well as the activation status of resident microglia in the brains of normal and transgenic mice acutely ablated of peripheral dendritic cells (DCs) in vivo. VSV encephalitis was characterized by a pronounced infiltrate of myeloid cells (CD45(high)CD11b(+)) and CD8(+) T cells containing a subset that was specific for the immunodominant VSV nuclear protein epitope. This T cell response correlated temporally with a rapid and sustained upregulation of MHC class I expression on microglia, whereas class II expression was markedly delayed. Ablation of peripheral DCs profoundly inhibited the inflammatory response as well as infiltration of virus-specific CD8(+) T cells. Unexpectedly, the VSV-induced interferon-gamma (IFN-gamma) response in the CNS remained intact in DC-deficient mice. Thus, both the inflammatory and certain components of the adaptive primary antiviral immune response in the CNS are dependent on peripheral DCs in vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.