ReviewCellular and molecular neurobiology2009
Beyond the rat models of human neurodegenerative disorders.
Review in Cellular and molecular neurobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Fecal microbiota transplantation from psychiatric patients to mice - systematic review of methodologies and a call for standardization.Translational psychiatry · 2026Pooled it
- Monocyte-macrophage SAMHD1 alleviates EAMG by modulating the cGAS-STING pathway.Journal of neuroinflammation · 2026Article
- Development and Optimization of a Multilayer Rat Purkinje Neuron Culture.Cerebellum (London, England) · 2024Article
- Co-administration of exercise training and melatonin on the function of diabetic heart tissue: a systematic review and meta-analysis of rodent models.Diabetology & metabolic syndrome · 2023Article
- An App knock-in rat model for Alzheimer's disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments.Cell research · 2022Article
- Animal Model for Lower Urinary Tract Dysfunction in Parkinson's Disease.International journal of molecular sciences · 2020Review
- Stem Cell Therapy for Neurogenic Bladder Dysfunction in Rodent Models: A Systematic Review.International neurourology journal · 2020Article
- CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases.Molecular neurodegeneration · 2015Review
- Mesengenic differentiation: comparison of human and rat bone marrow mesenchymal stem cells.International journal of stem cells · 2014Article
- Modeling human neurodegenerative diseases in transgenic systems.Human genetics · 2012Review
- Expression of neural markers by undifferentiated rat mesenchymal stem cells.Journal of biomedicine & biotechnology · 2012Article
- Population-averaged diffusion tensor imaging atlas of the Sprague Dawley rat brain.NeuroImage · 2011Article
- Zinc Finger Nucleases: A new era for transgenic animals.Annals of neurosciences · 2011Review
- Synergy of image analysis for animal and human neuroimaging supports translational research on drug abuse.Frontiers in psychiatry · 2011Article
- Experimental animal models of neurogenic bladder dysfunction.International neurourology journal · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rat is a model of choice in biomedical research for over a century. Currently, the rat presents the best "functionally" characterized mammalian model system. Despite this fact, the transgenic rats have lagged behind the transgenic mice as an experimental model of human neurodegenerative disorders. The number of transgenic rat models recapitulating key pathological hallmarks of Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, or human tauopathies is still limited. The reason is that the transgenic rats remain more difficult to produce than transgenic mice. The gene targeting technology is not yet established in rats due to the lack of truly totipotent embryonic stem cells and cloning technology. This extremely powerful technique has given the mouse a clear advantage over the rat in generation of new transgenic models. Despite these limitations, transgenic rats have greatly expanded the range of potential experimental approaches. The large size of rats permits intrathecal administration of drugs, stem cell transplantation, serial sampling of the cerebrospinal fluid, microsurgical techniques, in vivo nerve recordings, and neuroimaging procedures. Moreover, the rat is routinely employed to demonstrate therapeutic efficacy and to assess toxicity of novel therapeutic compounds in drug development. Here we suggest that the rat constitutes a slightly underestimated but perspective animal model well-suited for understanding the mechanisms and pathways underlying the human neurodegenerative disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.