ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2009
Inhibitory effects of erythromycin on wear debris-induced VEGF/Flt-1 gene production and osteolysis.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- The potential effects of microplastics on human health: What is known and what is unknown.Ambio · 2022Review
- Polystyrene and Polyethylene Microplastics Decrease Cell Viability and Dysregulate Inflammatory and Oxidative Stress Markers of MDCK and L929 Cells In Vitro.Exposure and health · 2022Article
- 20(S)-Protopanaxadiol Inhibits Titanium Particle-Induced Inflammatory Osteolysis and RANKL-Mediated Osteoclastogenesis via MAPK and NF-κB Signaling Pathways.Frontiers in pharmacology · 2018Article
- Intermittent Administration of Parathyroid Hormone [1-34] Prevents Particle-Induced Periprosthetic Osteolysis in a Rat Model.PloS one · 2015Article
- Are biologic treatments a potential approach to wear- and corrosion-related problems?Clinical orthopaedics and related research · 2014Review
- Extracellular matrix degradation and tissue remodeling in periprosthetic loosening and osteolysis: focus on matrix metalloproteinases, their endogenous tissue inhibitors, and the proteasome.BioMed research international · 2013Review
- Inhibiting wear particles-induced osteolysis with naringin.International orthopaedics · 2013Article
- Protection against titanium particle-induced inflammatory osteolysis by the proteasome inhibitor bortezomib in vivo.Inflammation · 2012Article
- Bone turnover markers correlate with implant fixation in a rat model using LPS-doped particles to induced implant loosening.Journal of biomedical materials research. Part A · 2012Article
- Polyethylene and metal wear particles: characteristics and biological effects.Seminars in immunopathology · 2011Review
- "Old drugs" for the treatment of rheumatoid arthritis: will the cholinergic anti-inflammatory pathway and anti-nociceptive pathway work?Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesA highly vascularized and inflammatory periprosthetic tissue augments the progress of aseptic loosening, a major clinical problem after total joint replacement. The purpose of this study is to investigate the effect of erythromycin (EM) on ultra high molecular weight polyethylene (UHMWPE) particle-induced VEGF/VEGF receptor 1 (Flt-1) gene production and inflammatory osteolysis in a mouse model.
methodsUHMWPE particles were introduced into established air pouches on BALB/c mice, followed by implantation of calvaria bone from syngeneic littermates. EM treatment started 2 weeks after bone implantation (5 mg/kg day, i.p. injection). Mice without drug treatment as well as mice injected with saline alone were included. Pouch tissues were harvested 2 weeks after bone implantation. Expression of VEGF, Flt-1, RANKL, IL-1, TNF and CD68 was measured by immunostain and RT-PCR, and implanted bone resorption was analyzed by micro-CT (muCT).
resultsExposure to UHMWPE induced pouch tissue inflammation, increase of VEGF/Flt-1 proteins, and increased bone resorption. EM treatment significantly improved UHMWPE particle-induced tissue inflammation, reduced VEGF/Flt-1 protein expression, and diminished the number of TRAP(+) cells, as well as the implanted bone resorption.
conclusionThis study demonstrated that EM inhibited VEGF and Flt-1 gene expression. The molecular mechanism of EM action on VEGF/Flt-1 signaling-mediated osteoclastogenesis warrants further investigation.
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