ArticlePloS one2009
Genome sequence of the pathogenic intestinal spirochete brachyspira hyodysenteriae reveals adaptations to its lifestyle in the porcine large intestine.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 111 citations in OpenAlex.
- Genomic insights into the population structure, antimicrobial resistance, and virulence ofMicrobiology spectrum · 2025Article
- Experimental Infection of Pigs with a ST 245Veterinary sciences · 2022Article
- Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistantEFSA journal. European Food Safety Authority · 2022Article
- Whole-genome analyses reveal a novel prophage and cgSNPs-derived sublineages of Brachyspira hyodysenteriae ST196.BMC genomics · 2022Article
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- Whole-Genome Sequencing ofFrontiers in microbiology · 2021Article
- Evidence of homologous recombination as a driver of diversity inMicrobial genomics · 2020Article
- Differential expression of hemolysin genes in weakly and strongly hemolytic Brachyspira hyodysenteriae strains.BMC veterinary research · 2020Article
- Spirochete Flagella and Motility.Biomolecules · 2020Review
- The Southern Bluefin Tuna Mucosal Microbiome Is Influenced by Husbandry Method, Net Pen Location, and Anti-parasite Treatment.Frontiers in microbiology · 2020Article
- Role of Sialic Acid in Brachyspira hyodysenteriae Adhesion to Pig Colonic Mucins.Infection and immunity · 2019Article
- Weakly haemolytic variants of Brachyspira hyodysenteriae newly emerged in Europe belong to a distinct subclade with unique genetic properties.Veterinary research · 2019Article
- The Spirochete Brachyspira pilosicoli, Enteric Pathogen of Animals and Humans.Clinical microbiology reviews · 2018Review
- Identification of a New Antimicrobial Resistance Gene Provides Fresh Insights Into Pleuromutilin Resistance inFrontiers in microbiology · 2018Article
- Article
- Identification of constraints influencing the bacterial genomes evolution in the PVC super-phylum.BMC evolutionary biology · 2017Article
- Characterization and Recognition of Brachyspira hampsonii sp. nov., a Novel Intestinal Spirochete That Is Pathogenic to Pigs.Journal of clinical microbiology · 2016Article
- Complete Genome Sequence of Brachyspira hyodysenteriae Type Strain B-78 (ATCC 27164).Genome announcements · 2016Article
- Compartmentalization in PVC super-phylum: evolution and impact.Biology direct · 2016Article
- Variation in hemolytic activity of Brachyspira hyodysenteriae strains from pigs.Veterinary research · 2016Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brachyspira hyodysenteriae is an anaerobic intestinal spirochete that colonizes the large intestine of pigs and causes swine dysentery, a disease of significant economic importance. The genome sequence of B. hyodysenteriae strain WA1 was determined, making it the first representative of the genus Brachyspira to be sequenced, and the seventeenth spirochete genome to be reported. The genome consisted of a circular 3,000,694 base pair (bp) chromosome, and a 35,940 bp circular plasmid that has not previously been described. The spirochete had 2,122 protein-coding sequences. Of the predicted proteins, more had similarities to proteins of the enteric Escherichia coli and Clostridium species than they did to proteins of other spirochetes. Many of these genes were associated with transport and metabolism, and they may have been gradually acquired through horizontal gene transfer in the environment of the large intestine. A reconstruction of central metabolic pathways identified a complete set of coding sequences for glycolysis, gluconeogenesis, a non-oxidative pentose phosphate pathway, nucleotide metabolism, lipooligosaccharide biosynthesis, and a respiratory electron transport chain. A notable finding was the presence on the plasmid of the genes involved in rhamnose biosynthesis. Potential virulence genes included those for 15 proteases and six hemolysins. Other adaptations to an enteric lifestyle included the presence of large numbers of genes associated with chemotaxis and motility. B. hyodysenteriae has diverged from other spirochetes in the process of accommodating to its habitat in the porcine large intestine.
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