Evidence map›Paper›PMID 19262593›Full record

ArticleNature clinical practice. Neurology2009

Fatal Epstein-Barr virus encephalitis in a 12-year-old child: an underappreciated neurological complication?

Ariane Biebl, Christine Webersinke, Bernadette Traxler, Brigitte Povysil, Dieter Furthner, Klaus Schmitt, Serge Weis

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Nature clinical practice. Neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Epstein-Barr virus and the immune microenvironment in multiple sclerosis: Insights from high-dimensional brain tissue imaging.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. Expanding the spectrum of neurological disease associated with Epstein-Barr virus activity.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2011
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Ariane BieblDepartment of Pediatrics, Children's Hospital, Linz, Austria. ariane.biebl@gespag.at
Christine Webersinke
Bernadette Traxler
Brigitte Povysil
Dieter Furthner
Klaus Schmitt
Serge Weis
MRC Laboratory of Molecular Biology · GBWomen's General Hospital · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA 12-year-old boy presented to a community hospital with fever, malaise and fatigue. A polymerase chain reaction test of the cerebrospinal fluid was positive for Epstein-Barr virus. Despite intensive care treatment and antiviral drugs, the patient died 1 month after his initial presentation. INVESTIGATIONS: Physical examination, polymerase chain reaction analysis of the cerebrospinal fluid, brain MRI, immunohistochemistry and molecular biological investigations of postmortem brain samples. DIAGNOSIS: Epstein-Barr Virus encephalitis. MANAGEMENT: Aciclovir, intensive care treatment with intubation, sedation, antiepileptic drugs.

Indexed as

AcyclovirAnticonvulsantsAntiviral AgentsBrainChildCritical CareEncephalitis, ViralEpstein-Barr Virus InfectionsFatal OutcomeHerpesvirus 4, HumanHumansImmunohistochemistryMagnetic Resonance ImagingMalePolymerase Chain ReactionProcedural SedationAcyclovirAnticonvulsantsAntiviral Agents

Identifiers

PMID19262593
OpenAlexW2054949288

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.