Evidence map›Paper›PMID 19262464›Full record

Trial reportClinical pharmacology and therapeutics2009

Factors associated with exacerbation of heart failure include treatment adherence and health literacy skills.

M D Murray, W Tu, J Wu, D Morrow, F Smith, D C Brater

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical pharmacology and therapeutics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  4. Health Literacy and Heart Failure: A Systematic Review.The Journal of cardiovascular nursing
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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

M D MurrayDivision of Pharmaceutical Outcomes and Policy, University of North Carolina Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. mick@unc.edu
W Tu
J Wu
D Morrow
F Smith
D C Brater

Funding

CLINICAL PHARMACOLOGY OF NSAIDS IN THE ELDERLYR01AG007631 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI BRATER, D CRAIG · 1988 to 2004
$1.6M
IMPROVING DRUG USE FOR ELDERLY HEART FAILURE PATIENTSR01AG019105 · NIA · PURDUE UNIVERSITY WEST LAFAYETTE · PI MURRAY, MICHAEL D · 2000 to 2003
$1.5M
Health literacy and aging: A process-knowledge approachR01AG031718 · NIA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI MORROW, DANIEL G · 2008 to 2012
$1.4M
NIA NIH HHS R01 AG007631NIA NIH HHS R01 AG019105NIA NIH HHS R01 AG031718NIA NIH HHS R01 AG07631NIA NIH HHS R01 AG19105
6 · The paper itself

Abstract

We determined the factors associated with exacerbation of heart failure, using a cohort (n = 192) nested within a randomized trial at a university-affiliated ambulatory practice. Factors associated with emergency or hospital care included left ventricular ejection fraction, hematocrit and serum sodium levels, refill adherence, and the ability to read a prescription label. Refill adherence of <40% was associated with a threefold higher incidence of hospitalization for heart failure than a refill adherence of >or=80% (P = 0.002). In multivariable analysis, prescription label reading skills were associated with a lower incidence of heart failure-specific emergency care (incidence rate ratio, 0.76; 95% confidence interval (CI), 0.19-0.69), and participants with adequate health literacy had a lower risk of hospitalization for heart failure (incidence rate ratio, 0.34; 95% CI, 0.15-0.76). We conclude that inadequate treatment adherence and health literacy skills are key factors in the exacerbation of heart failure. These findings emphasize the need for careful instruction of patients about their medications.

Indexed as

Medication AdherencePatient Education as TopicAgedCohort StudiesEmergency Service, HospitalFemaleHeart FailureHematocritHospitalizationHumansInsurance Claim ReviewMaleMedical AssistanceMiddle AgedSodiumStroke VolumeSodium

Identifiers

PMID19262464
PMCPMC2855238

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.