ReviewCell adhesion & migration
PtdIns(3,4)P2 instigates focal adhesions to generate podosomes.
Review in Cell adhesion & migration. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Phosphoinositide signaling at the cytoskeleton in the regulation of cell dynamics.Cell death & disease · 2025Review
- Protein dynamics at invadopodia control invasion-migration transitions in melanoma cells.Cell death & disease · 2023Article
- Excitable networks controlling cell migration during development and disease.Seminars in cell & developmental biology · 2020Review
- The regulators of BCR signaling during B cell activation.Blood science (Baltimore, Md.) · 2019Review
- Atypical matrix adhesions guide cell division.Nature cell biology · 2018Article
- The role and regulation of Rab40b-Tks5 complex during invadopodia formation and cancer cell invasion.Journal of cell science · 2016Article
- Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation.Oncotarget · 2016Article
- Tir Is Essential for the Recruitment of Tks5 to Enteropathogenic Escherichia coli Pedestals.PloS one · 2015Article
- Regulation of invadopodia by the tumor microenvironment.Cell adhesion & migration · 2014Review
- The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms.The Journal of cell biology · 2013Article
- Article
- Metabolic regulation of invadopodia and invasion by acetyl-CoA carboxylase 1 and de novo lipogenesis.PloS one · 2012Article
- Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis.PloS one · 2012Article
- Membrane lipids in invadopodia and podosomes: key structures for cancer invasion and metastasis.Oncotarget · 2010Review
- Effects of chemical inhibition of N-WASP, a critical regulator of actin polymerization on aqueous humor outflow through the conventional pathway.Experimental eye research · 2010Article
- Real-time monitoring of hematopoietic cell interaction with fibronectin fragment: the effect of histone deacetylase inhibitors.Cell adhesion & migrationArticle
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell-to-extracellular matrix (ECM) adhesion plays important roles in various biological events, such as proliferation, differentiation and migration. Distinct from other types of adhesion structures (focal complexes, focal adhesions and so on), podosomes and invadopodia are thought to have additional functions beyond attachment, possibly including invasion into the ECM. for podosomes and invadopodia to invade into the ECM, molecules involved in adhesion, actin polymerization and ECM degradation must be recruited to sites of action. Our recent study demonstrated that podosomes form near newly formed focal adhesions via the minimally expressed phosphoinositide PtdIns(3,4) P2-mediated recruitment of the Tks5-Grb2 scaffold, followed by the accumulation of N-WASP. Although this study demonstrated details of molecular interplay during the transformation of focal adhesion, its regulation in the in vivo invasion process remains to be clarified. Here, we discuss the molecular bases of the transformation of focal adhesions to podosomes/invadopodia based on current understanding.
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