ArticleCell adhesion & migration
Interplay between adhesion turnover and cytoskeleton dynamics in the control of growth cone migration.
Article in Cell adhesion & migration. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- β-catenin-α-catenin and actomyosin signaling differentially regulate growth cone contours and axon undulation and branching of retinal ganglion cellsFrontiers in cellular neuroscience · 2025Article
- Two-tiered coupling between flowing actin and immobilized N-cadherin/catenin complexes in neuronal growth cones.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- β1-Integrin cytoskeletal signaling regulates sensory neuron response to matrix dimensionality.Neuroscience · 2013Article
- Growth cone travel in space and time: the cellular ensemble of cytoskeleton, adhesion, and membrane.Neuron · 2012Review
- The formation of actin waves during regeneration after axonal lesion is enhanced by BDNF.Scientific reports · 2011Article
- Trafficking guidance receptors.Cold Spring Harbor perspectives in biology · 2010Review
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Authors and funding
1 author.
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Abstract
The migration of neuronal growth cones, driving axon extension, is a fascinating process which has been subject of intense investigation over several decades. Many of the key underlying molecules, in particular adhesion proteins at the cell membrane which allow for target recognition and binding, and cytoskeleton filaments and motors which power locomotion have been identified. However, the precise mechanisms by which growth cones coordinate, in time and space, the transmission of forces generated by the cytoskeleton to the turnover of adhesion proteins are still partly unresolved. To get a better grasp at these processes, we put here in relation the turnover rate of ligand/receptor adhesions and the degree of mechanical coupling between cell adhesion receptors and the actin rearward flow. These parameters were obtained recently for N-cadherin and IgCAM based adhesions using ligand-coated microspheres in combination with optical tweezers and photo-bleaching experiments. We show that the speed of growth cone migration requires both a fairly rapid adhesion dynamics and a strong physical connection between adhesive sites and the cytoskeleton.
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Registered trials
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