ReviewCell adhesion & migration
Desmosomes: just cell adhesion or is there more?
Review in Cell adhesion & migration. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Downregulation of γ-Catenin by miR-195-5p Inhibits Colon Cancer Progression, Regulating Desmosome Function.International journal of molecular sciences · 2023Article
- Serological Biomarkers and Their Detection in Autoimmune Bullous Skin Diseases.Dermatology practical & conceptual · 2022Review
- Identification of Desmoglein-2 as a novel target of Helicobacter pylori HtrA in epithelial cells.Cell communication and signaling : CCS · 2021Article
- Dysregulation of Intestinal Epithelial Cell RIPK Pathways Promotes Chronic Inflammation in the IBD Gut.Frontiers in immunology · 2019Review
- Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination.Nature communications · 2018Article
- The Evolving Story of Autoantibodies in Pemphigus Vulgaris: Development of the "Super Compensation Hypothesis".Frontiers in medicine · 2018Review
- Article
- Prediction of survival for patients with pemphigus vulgaris and pemphigus foliaceus: a retrospective cohort study.Orphanet journal of rare diseases · 2015Article
- Integrating animal models and in vitro tissue models to elucidate the role of desmosomal proteins in diseases.Cell communication & adhesion · 2014Review
- Plakoglobin as a regulator of desmocollin gene expression.The Journal of investigative dermatology · 2013Article
- Structure, function, and regulation of desmosomes.Progress in molecular biology and translational science · 2013Review
- Loss of Desmocollin 3 in skin tumor development and progression.Molecular carcinogenesis · 2012Article
- Altered desmosomal proteins in granulomatous myocarditis and potential pathogenic links to arrhythmogenic right ventricular cardiomyopathy.Circulation. Arrhythmia and electrophysiology · 2011Article
- The role of intracellular protein O-glycosylation in cell adhesion and disease.Journal of biomedical research · 2011Article
- Plakoglobin regulates cell motility through Rho- and fibronectin-dependent Src signaling.Journal of cell science · 2010Article
- The catenin family at a glance.Journal of cell science · 2010Review
- Desmosomes at a glance.Journal of cell science · 2009Article
- Loss of desmocollin 3 in mice leads to epidermal blistering.Journal of cell science · 2008Article
- Naxos Disease: The Model for Scientific Discovery.International journal of trichologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Desmosomes are cell adhesion structures (junctions) that are particularly abundant in cells derived from the ectodermal lineages. These junctions are required to maintain the integrity of organs subjected to mechanical stress, in particular the skin and the heart. This conclusion is partially based on tissue fragility phenotypes observed in mice with null mutations in certain desmosomal genes. Furthermore, patients have been identified that develop severe skin disorders, and even fatal heart diseases, due to impaired desmosome function. Nevertheless, desmosomes are more than cellular glue. New evidence suggests that these junctions can transmit signals from the extracellular environment to the nucleus, for example by controling the cytoplasmic pool of transcriptional co-factors that belong to the armadillo family of desmosomal proteins (i.e. plakoglobin, plakophilins). Understanding the signaling properties of desmosomes will provide new insights into developmental processes such as skin and skin appendage development. Furthermore, there is evidence to suggest that abnormal signaling through these junctions contributes to the symptoms of certain skin and heart diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.