ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2009
Baroreflex sensitivity varies during the rat estrous cycle: role of gonadal steroids.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- A closed-loop approach to monitor and manipulate the neural control of blood pressure.Journal of neuroscience methods · 2025Article
- Exogenous estradiol increases cardiovagal baroreflex sensitivity during a hypertensive stimulus in premenopausal young women.American journal of physiology. Heart and circulatory physiology · 2025Article
- Blockade of insulin receptor signaling in the medullary cardiovascular centers impairs open-loop arterial baroreflex function via attenuated neural arc in healthy male rats.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Alleviating Hypertension by Selectively Targeting Angiotensin Receptor-Expressing Vagal Sensory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Sex Differences and Caffeine Impact in Adenosine-Induced Hyperemia.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- Sex differences in cognitive flexibility are driven by the estrous cycle and stress-dependent.Frontiers in behavioral neuroscience · 2022Article
- Preserved glycemic control and baroreflex efficacy in young adult hypertensive female obese Zucker rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Comparison of high-fat style diet-induced dysregulation of baroreflex control of renal sympathetic nerve activity in intact and ovariectomized female rats: Renal sympathetic nerve activity in high-fat style diet fed intact and ovariectomized female rats.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Obesity: sex and sympathetics.Biology of sex differences · 2020Review
- Laterality Influences Central Integration of Baroreceptor Afferent Input in Male and Female Sprague Dawley Rats.Frontiers in physiology · 2020Article
- Resistance to the sympathoexcitatory effects of insulin and leptin in late pregnant rats.The Journal of physiology · 2019Article
- The Role of Angiotensin II Infusion on the Baroreflex Sensitivity and Renal Function in Intact and Bilateral Renal Denervation Rats.Advanced biomedical research · 2018Article
- Estrogen Replacement Reduces Oxidative Stress in the Rostral Ventrolateral Medulla of Ovariectomized Rats.Oxidative medicine and cellular longevity · 2016Article
- Leptin differentially increases sympathetic nerve activity and its baroreflex regulation in female rats: role of oestrogen.The Journal of physiology · 2015Article
- Bisphenol A alters autonomic tone and extracellular matrix structure and induces sex-specific effects on cardiovascular function in male and female CD-1 mice.Endocrinology · 2015Article
- Sex differences in T-lymphocyte tissue infiltration and development of angiotensin II hypertension.Hypertension (Dallas, Tex. : 1979) · 2014Article
- Lack of effect of ovarian cycle and oral contraceptives on baroreceptor and nonbaroreceptor control of sympathetic nerve activity in healthy women.American journal of physiology. Heart and circulatory physiology · 2012Article
- Baroreflex function in females: changes with the reproductive cycle and pregnancy.Gender medicine · 2012Review
- Evidence that the G protein-coupled membrane receptor GPR30 contributes to the cardiovascular actions of estrogen.Gender medicine · 2011Review
- Sex differences in baroreflex sensitivity, heart rate variability, and end organ damage in the TGR(mRen2)27 rat.American journal of physiology. Heart and circulatory physiology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Baroreflex sensitivity (BRS) increases in women during the luteal phase of the menstrual cycle, when gonadal hormones are elevated, but whether a similar cycle-dependent variation in BRS occurs in rats is unknown. In addition, whether cyclic BRS changes depend on gonadal steroids has not been previously investigated. To test these hypotheses, BRS was determined in cycling female rats using two approaches: 1) baroreflex control of renal sympathetic nerve activity (RSNA) in anesthetized rats; 2) cardiovagal spontaneous BRS (sBRS) in conscious rats instrumented for continuous telemetric measurements of mean arterial pressure (MAP) and heart rate (HR). MAP, HR, and sBRS were also measured in rats 2-3 and 5-6 wk following ovariectomy (OVX), to eliminate gonadal steroids. In anesthetized rats, RSNA BRS gain was increased (P < 0.01) during proestrus (-4.8+/-0.5% control/mmHg) compared with diestrus/estrus (-2.8 +/- 0.3% control/mmHg). Similarly, a proestrous peak in sBRS was observed in conscious rats (1.66 +/- 0.07 ms/mmHg, proestrus; 1.48 +/- 0.06 ms/mmHg, diestrus/estrus; P < 0.001). OVX eliminated estrous cycle-induced variation in sBRS. In addition, OVX reduced (P < 0.05) diurnal variations in MAP (5.9 +/- 0.3 vs. 3.9 +/- 0.5 mmHg) and HR [54 +/- 4 vs. 39 +/- 3 beats per minute (bpm)], and abolished diurnal variations in sBRS. Finally, while MAP, HR, and sBRS were decreased 2-3 wk following OVX, approximately 3 wk later, MAP and sBRS increased, and HR decreased further. No changes in MAP, HR, or sBRS were seen with time in sham OVX controls. In summary, RSNA and cardiovagal sBRS vary during the rat estrous cycle, and this variation is abolished by OVX. We conclude that sex steroid hormones are required for both cyclic and diurnal changes in BRS in rats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.