ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Auditory input to CNS is acquired coincidentally with development of inner ear after formation of functional afferent pathway in zebrafish.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 50 citations in OpenAlex.
- Birthdate aligns vestibular sensory neurons with central and motor partners across a sensorimotor reflex circuit for gaze stabilization.Development (Cambridge, England) · 2026Article
- Development of the semicircular canals and otolithic organs of the vertebrate inner ear.Current topics in developmental biology · 2025Review
- Defects in Exosome Biogenesis Are Associated with Sensorimotor Defects in ZebrafishThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Silicon-Rhodamine Functionalized Evocalcet Probes Potently and Selectively Label Calcium Sensing ReceptorsACS pharmacology & translational science · 2024Article
- Cyfip2 controls the acoustic startle threshold through FMRP, actin polymerization, and GABAbioRxiv : the preprint server for biology · 2024Article
- Decreased activity in zebrafish larvae exposed to glyphosate-based herbicides during development-potential mediation by glucocorticoid receptor.Frontiers in toxicology · 2024Article
- Differential expression of mechanotransduction complex genes in auditory/vestibular hair cells in zebrafish.Frontiers in molecular neuroscience · 2023Article
- Tiltable objective microscope visualizes selectivity for head motion direction and dynamics in zebrafish vestibular system.Nature communications · 2022Article
- CNS Hypomyelination Disrupts Axonal Conduction and Behavior in Larval Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Behavioral Role of the Reciprocal Inhibition between a Pair of Mauthner Cells during Fast Escapes in Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- The genetics of hair-cell function in zebrafish.Journal of neurogenetics · 2017Review
- Behavioral methods for the functional assessment of hair cells in zebrafish.Frontiers of medicine · 2017Review
- Defects of the Glycinergic Synapse in Zebrafish.Frontiers in molecular neuroscience · 2016Review
- Ribbon synapses in zebrafish hair cells.Hearing research · 2015Review
- Sensory hair cell death and regeneration in fishes.Frontiers in cellular neuroscience · 2015Review
- Electrical synaptic transmission in developing zebrafish: properties and molecular composition of gap junctions at a central auditory synapse.Journal of neurophysiology · 2014Article
- Manipulation of BK channel expression is sufficient to alter auditory hair cell thresholds in larval zebrafish.The Journal of experimental biology · 2014Article
- PFOS induces behavioral alterations, including spontaneous hyperactivity that is corrected by dexamfetamine in zebrafish larvae.PloS one · 2014Article
- Early development of hearing in zebrafish.Journal of the Association for Research in Otolaryngology : JARO · 2013Article
- Development of the acoustically evoked behavioral response in larval plainfin midshipman fish, Porichthys notatus.PloS one · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Auditory perception in vertebrates depends on transduction of sound into neural signals in the inner ear hair cells (HCs) and on transmission of these signals to the brain through auditory (VIIIth) nerve afferents. To investigate the developmental acquisition of auditory inputs by the CNS, we have electrophysiologically and morphologically examined the process of acquisition of auditory responsiveness by zebrafish macular HCs and the Mauthner cells (M-cells) in vivo. The M-cells are a paired large reticulospinal neurons in the hindbrain; they receive direct inputs from the VIIIth nerve afferents and initiate an acoustic startle response. Whole-cell recordings from the M-cells showed that sound-evoked postsynaptic currents were first observed around 40 h postfertilization (hpf); during subsequent development, onset latency decreased and amplitude increased. The appearance and development of microphonic potentials in the inner ear coincided with those of the acoustic responses of the M-cell, whereas the functional auditory circuits from the macular HCs to the M-cell were already formed at 27 hpf. These results suggest that the functional maturation of inner ear after formation of the auditory pathway is a critical process in the acquisition of auditory inputs by CNS neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.