ArticleProceedings of the National Academy of Sciences of the United States of America2009
PML depletion disrupts normal mammary gland development and skews the composition of the mammary luminal cell progenitor pool.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 53 citations in OpenAlex.
- Promyelocytic leukemia protein regulates angiogenesis and epithelial-mesenchymal transition to limit metastasis in MDA-MB-231 breast cancer cells.Molecular oncology · 2023Article
- Genome Assembly and Evolutionary Analysis of the Mandarin Duck Aix galericulata Reveal Strong Genome Conservation among Ducks.Genome biology and evolution · 2022Article
- PML Regulates the Epidermal Differentiation Complex and Skin Morphogenesis during Mouse Embryogenesis.Genes · 2020Article
- PML Bodies in Mitosis.Cells · 2019Review
- Promyelocytic leukemia protein (PML) controls breast cancer cell proliferation by modulating Forkhead transcription factors.Molecular oncology · 2019Article
- Coordinated collective migration and asymmetric cell division in confluent human keratinocytes without wounding.Nature communications · 2018Article
- PML: Regulation and multifaceted function beyond tumor suppression.Cell & bioscience · 2018Review
- Myogenic differentiation triggers PML nuclear body loss and DAXX relocalization to chromocentres.Cell death & disease · 2017Article
- A Long-Lived Luminal Subpopulation Enriched with Alveolar Progenitors Serves as Cellular Origin of Heterogeneous Mammary Tumors.Stem cell reports · 2015Article
- Hormone-sensing mammary epithelial progenitors: emerging identity and hormonal regulation.Journal of mammary gland biology and neoplasia · 2015Review
- Article
- The role of PML in hematopoietic and leukemic stem cell maintenance.International journal of hematology · 2014Review
- Tip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expression.Cell death & disease · 2014Article
- PML-mediated signaling and its role in cancer stem cells.Oncogene · 2014Review
- USP11 regulates PML stability to control Notch-induced malignancy in brain tumours.Nature communications · 2014Article
- Tumor suppressive pathways in the control of neurogenesis.Cellular and molecular life sciences : CMLS · 2013Review
- Evidence for a multipotent mammary progenitor with pregnancy-specific activity.Breast cancer research : BCR · 2013Article
- The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3.Genes & development · 2012Article
- Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post-lactational regression.The Journal of pathology · 2012Article
- Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Nuclear domains of promyelocytic leukemia protein (PML) are known to act as signaling nodes in many cellular processes. Although the impact of PML expression in driving cell fate decisions for injured cells is well established, the function of PML in the context of tissue development is less well understood. Here, the in vivo role of PML in developmental processes in the murine mammary gland has been investigated. Data are presented showing that expression of PML is tightly regulated by three members of the Stat family of transcription factors that orchestrate the functional development of the mammary secretory epithelium during pregnancy. Developmental phenotypes were also discovered in the virgin and pregnant Pml null mouse, typified by aberrant differentiation of mammary epithelia with reduced ductal and alveolar development. PML depletion was also found to disturb the balance of two distinct luminal progenitor populations. Overall, it is shown that PML is required for cell lineage determination in bi-potent luminal progenitor cells and that the precise regulation of PML expression is required for functional differentiation of alveolar cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.