ArticleDevelopment (Cambridge, England)2009
Caudal-like PAL-1 directly activates the bodywall muscle module regulator hlh-1 in C. elegans to initiate the embryonic muscle gene regulatory network.
Article in Development (Cambridge, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Conversion of Germ Cells to Somatic Cell Types inJournal of developmental biology · 2020Review
- Multilevel regulation of muscle-specific transcription factor hlh-1 during Caenorhabditis elegans embryogenesis.Development genes and evolution · 2020Article
- Caudal-dependent cell positioning directs morphogenesis of the C. elegans ventral epidermis.Developmental biology · 2020Article
- Diverse Roles of PUF Proteins in Germline Stem and Progenitor Cell Development inFrontiers in cell and developmental biology · 2020Review
- DOT1L complex suppresses transcription from enhancer elements and ectopic RNAi inRNA (New York, N.Y.) · 2019Article
- Chromatin accessibility dynamics reveal novel functional enhancers inGenome research · 2017Article
- Genome-wide discovery of active regulatory elements and transcription factor footprints inGenome research · 2017Article
- Combinatorial decoding of the invariant C. elegans embryonic lineage in space and time.Genesis (New York, N.Y. : 2000) · 2016Review
- Genome-wide epigenomic profiling for biomarker discovery.Clinical epigenetics · 2016Review
- Repression of somatic cell fate in the germline.Cellular and molecular life sciences : CMLS · 2015Review
- Quantitative Differences in Nuclear β-catenin and TCF Pattern Embryonic Cells in C. elegans.PLoS genetics · 2015Article
- MED GATA factors promote robust development of the C. elegans endoderm.Developmental biology · 2015Article
- Identification of genes driving lineage divergence from single-cell gene expression data in C. elegans.Developmental biology · 2014Article
- The TRIM-NHL protein LIN-41 controls the onset of developmental plasticity in Caenorhabditis elegans.PLoS genetics · 2014Article
- Mapping genome-wide transcription factor binding sites in frozen tissues.Epigenetics & chromatin · 2013Article
- The landscape of RNA polymerase II transcription initiation in C. elegans reveals promoter and enhancer architectures.Genome research · 2013Article
- Integrative analysis of C. elegans modENCODE ChIP-seq data sets to infer gene regulatory interactions.Genome research · 2013Article
- Transcription factor redundancy and tissue-specific regulation: evidence from functional and physical network connectivity.Genome research · 2012Article
- Network inference of pal-1 lineage-specific regulation in the C. elegans embryo by structural equation modeling.Bioinformation · 2012Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Previous work in C. elegans has shown that posterior embryonic bodywall muscle lineages are regulated through a genetically defined transcriptional cascade that includes PAL-1/Caudal-mediated activation of muscle-specific transcription factors, including HLH-1/MRF and UNC-120/SRF, which together orchestrate specification and differentiation. Using chromatin immunoprecipitation (ChIP) in embryos, we now demonstrate direct binding of PAL-1 in vivo to an hlh-1 enhancer element. Through mutational analysis of the evolutionarily conserved sequences within this enhancer, we identify two cis-acting elements and their associated transacting factors (PAL-1 and HLH-1) that are crucial for the temporal-spatial expression of hlh-1 and proper myogenesis. Our data demonstrate that hlh-1 is indeed a direct target of PAL-1 in the posterior embryonic C. elegans muscle lineages, defining a novel in vivo binding site for this crucial developmental regulator. We find that the same enhancer element is also a target of HLH-1 positive auto regulation, underlying (at least in part) the sustained high levels of CeMyoD in bodywall muscle throughout development. Together, these results provide a molecular framework for the gene regulatory network activating the muscle module during embryogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.