ArticleDigestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver2009
Determination of Helicobacter pylori virulence by analysis of the cag pathogenicity island isolated from Iranian patients.
Article in Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Effect of sub-MIC values of metronidazole, ciprofloxacin, and imipenem on the growth and toxin production inGastroenterology and hepatology from bed to bench · 2019Article
- Prevalence ofGastroenterology and hepatology from bed to bench · 2019Article
- Evaluating the relationship between serum immunoglobulin G (IgG) and A (IgA) anti-CagA antibody and theIranian journal of microbiology · 2017Article
- Eosinophilic gastroenteritis; a report of two cases with different presentations.Gastroenterology and hepatology from bed to bench · 2017Article
- Occurrence ofGastroenterology and hepatology from bed to bench · 2017Article
- Pancreatic adenocarcinoma protein-protein interaction network analysis.Gastroenterology and hepatology from bed to bench · 2017Article
- Study of prevalence, distribution and clinical significance ofGastroenterology and hepatology from bed to bench · 2017Article
- ATP binding cassette and cholecystokinin A receptor genetic variations in gallstone susceptibility.Gastroenterology and hepatology from bed to bench · 2017Article
- Protein profiling of infected human gastric epithelial cells with an IranianGastroenterology and hepatology from bed to bench · 2017Article
- Management of multi-drug resistantGastroenterology and hepatology from bed to bench · 2017Review
- The evaluation of functional results before and after laparoscopic Heller myotomy for achalasia: a single center experience.Gastroenterology and hepatology from bed to bench · 2017Article
- Helicobacter pylori and gastric cancer: a state of the art review.Gastroenterology and hepatology from bed to bench · 2015Review
- EPIYA motiefs of cagA and upper gastrointestinal diseases.Gastroenterology and hepatology from bed to bench · 2015Article
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Authors and funding
9 authors.
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Abstract
backgroundThe cag pathogenicity island (PAI), which can be divided into two parts, cagI and cagII, is the most well-known virulence factor of Helicobacter pylori.
aimsWe investigated the association between genetic variations within the cag PAI (cagA and cagE in the cagI and cagT in the cagII) and clinical outcomes in Iranian patients. SUBJECTS: A total of 231 patients including 182 patients with gastritis, 41 with peptic ulcer and 8 with gastric cancer.
methodsThe presence of the cagA, cagE and cagT genes were measured by polymerase chain reaction and the results were compared with clinical outcomes and gastric histology.
resultsThe cagA, cagE and cagT genes were found in 154 (66.7%), 90 (39.0%) and 70 (30.3%) of clinical isolates. At least 144 (62.3%) strains possessed partially deleted cag PAI (e.g., 69 [29.9%] strains were cagA-positive, but cagE and cagT-negative).
conclusionThe single genes as well as the combination of genes in the cag PAI appeared not to be useful markers to predict H. pylori-related diseases in Iranian patients. The genomic sequences of the cag PAI in Iranian strains might be considerably different from those in other geographic locations.
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