ArticleBMC evolutionary biology2009
Differential stepwise evolution of SARS coronavirus functional proteins in different host species.
Article in BMC evolutionary biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 51 citations in OpenAlex.
- Adaptive Evolution of the Fox Coronavirus Based on Genome-Wide Sequence Analysis.BioMed research international · 2022Article
- Implications of viral transmitted/founder (T/F) dynamics on vaccine development.Human vaccines & immunotherapeutics · 2021Article
- Variable routes to genomic and host adaptation among coronaviruses.Journal of evolutionary biology · 2021Article
- SARS-CoV-2 vaccines in advanced clinical trials: Where do we stand?Advanced drug delivery reviews · 2021Review
- The SARS-Coronavirus Infection Cycle: A Survey of Viral Membrane Proteins, Their Functional Interactions and Pathogenesis.International journal of molecular sciences · 2021Review
- The evolutionary history of ACE2 usage within the coronavirus subgenusbioRxiv : the preprint server for biology · 2021Article
- Immunity, virus evolution, and effectiveness of SARS-CoV-2 vaccines.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Review
- Evolution, Ecology, and Zoonotic Transmission of Betacoronaviruses: A Review.Frontiers in veterinary science · 2021Review
- The evolutionary history of ACE2 usage within the coronavirus subgenusVirus evolution · 2021Article
- Natural Selection Plays an Important Role in Shaping the Codon Usage of Structural Genes of the Viruses Belonging to theViruses · 2020Article
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- COVID-19: Time to exonerate the pangolin from the transmission of SARS-CoV-2 to humans.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2020Article
- Selective pressure on SARS-CoV-2 protein coding genes and glycosylation site prediction.Heliyon · 2020Article
- Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a newly emerged pathogen: an overview.Pathogens and disease · 2020Review
- Adaptive Evolution of Feline Coronavirus Genes Based on Selection Analysis.BioMed research international · 2020Article
- Epitope based vaccine prediction for SARS-COV-2 by deploying immuno-informatics approach.Informatics in medicine unlocked · 2020Article
- A recent origin of Orf3a from M protein across the coronavirus lineage arising by sharp divergence.Computational and structural biotechnology journal · 2020Article
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- Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference.Journal of virology · 2015Article
- Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSARS coronavirus (SARS-CoV) was identified as the etiological agent of SARS, and extensive investigations indicated that it originated from an animal source (probably bats) and was recently introduced into the human population via wildlife animals from wet markets in southern China. Previous studies revealed that the spike (S) protein of SARS had experienced adaptive evolution, but whether other functional proteins of SARS have undergone adaptive evolution is not known.
resultsWe employed several methods to investigate selective pressure among different SARS-CoV groups representing different epidemic periods and hosts. Our results suggest that most functional proteins of SARS-CoV have experienced a stepwise adaptive evolutionary pathway. Similar to previous studies, the spike protein underwent strong positive selection in the early and middle phases, and became stabilized in the late phase. In addition, the replicase experienced positive selection only in human patients, whereas assembly proteins experienced positive selection mainly in the middle and late phases. No positive selection was found in any proteins of bat SARS-like-CoV. Furthermore, specific amino acid sites that may be the targets of positive selection in each group are identified.
conclusionThis extensive evolutionary analysis revealed the stepwise evolution of different functional proteins of SARS-CoVs at different epidemic stages and different hosts. These results support the hypothesis that SARS-CoV originated from bats and that the spill over into civets and humans were more recent events.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.