ArticleTissue engineering. Part A2009
Chondrocytes and meniscal fibrochondrocytes differentially process aggrecan during de novo extracellular matrix assembly.
Article in Tissue engineering. Part A, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
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- Paracrine signals influence patterns of fibrocartilage differentiation in a lyophilized gelatin hydrogel for applications in rotator cuff repair.Biomaterials science · 2024Article
- Matrix metalloproteinases in rheumatoid arthritis and osteoarthritis: a state of the art review.Reumatologia · 2023Review
- Adult ovine chondrocytes in expansion culture adopt progenitor cell properties that are favorable for cartilage tissue engineering.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Review
- Potential of Soluble Decellularized Extracellular Matrix for Musculoskeletal Tissue Engineering - Comparison of Various Mesenchymal Tissues.Frontiers in cell and developmental biology · 2020Article
- Differential protein expression in human knee articular cartilage and medial meniscus using two different proteomic methods: a pilot analysis.BMC musculoskeletal disorders · 2018Article
- Gene expression profiles of the meniscus avascular phenotype: A guide for meniscus tissue engineering.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Co-culture with infrapatellar fat pad differentially stimulates proteoglycan synthesis and accumulation in cartilage and meniscus tissues.Connective tissue research · 2017Article
- Meniscus is more susceptible than cartilage to catabolic and anti-anabolic effects of adipokines.Osteoarthritis and cartilage · 2015Article
- Cell distribution and regenerative activity following meniscus replacement.International orthopaedics · 2014Article
- Impact of cellular microenvironment and mechanical perturbation on calcium signalling in meniscus fibrochondrocytes.European cells & materials · 2014Article
- Building an anisotropic meniscus with zonal variations.Tissue engineering. Part A · 2014Article
- Article
- A chondroitinase-ABC and TGF-β1 treatment regimen for enhancing the mechanical properties of tissue-engineered fibrocartilage.Acta biomaterialia · 2013Article
- Regional variations in the distribution and colocalization of extracellular matrix proteins in the juvenile bovine meniscus.Journal of anatomy · 2012Article
- Assessment of growth factor treatment on fibrochondrocyte and chondrocyte co-cultures for TMJ fibrocartilage engineering.Acta biomaterialia · 2011Article
- Maturation state-dependent alterations in meniscus integration: implications for scaffold design and tissue engineering.Tissue engineering. Part A · 2011Article
- Controlled delivery of transforming growth factor β1 by self-assembling peptide hydrogels induces chondrogenesis of bone marrow stromal cells and modulates Smad2/3 signaling.Tissue engineering. Part A · 2011Article
- Adult equine bone marrow stromal cells produce a cartilage-like ECM mechanically superior to animal-matched adult chondrocytes.Matrix biology : journal of the International Society for Matrix Biology · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Aggrecan is an extracellular matrix molecule that contributes to the mechanical properties of articular cartilage and meniscal fibrocartilage, but the abundance and processing of aggrecan in these tissues are different. The objective of this study was to compare patterns of aggrecan processing by chondrocytes and meniscal fibrochondrocytes in tissue explants and cell-agarose constructs. The effects of transforming growth factor-beta 1 (TGF-beta1) stimulation on aggrecan deposition and processing were examined, and construct mechanical properties were measured. Fibrochondrocytes synthesized and retained less proteoglycans than did chondrocytes in tissue explants and agarose constructs. In chondrocyte constructs, TGF-beta1 induced the accumulation of a 120-kDa aggrecan species previously detected in mature bovine cartilage. Fibrochondrocyte-seeded constructs contained high-molecular-weight aggrecan but lacked aggrecanase-generated fragments found in native, immature meniscus. In addition, reflecting the lesser matrix accumulation, fibrochondrocyte constructs had significantly lower compression moduli than did chondrocyte constructs. These cell type-specific differences in aggrecan synthesis, retention, and processing may have implications for the development of functional engineered tissue grafts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.