ArticleCroatian medical journal2009
Common variant in myocilin gene is associated with high myopia in isolated population of Korcula Island, Croatia.
Article in Croatian medical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Cardioneural ablation: Toward achieving uniformity in nomenclature, procedural approaches, and outcome measures.Heart rhythm · 2026Review
- IMI - Myopia Genetics Report.Investigative ophthalmology & visual science · 2019Review
- Insight into the molecular genetics of myopia.Molecular vision · 2017Review
- Genetic association of COL1A1 polymorphisms with high myopia in Asian population: a Meta-analysis.International journal of ophthalmology · 2016Article
- Association of COL1A1 polymorphism with high myopia: a Meta-analysis.International journal of ophthalmology · 2016Article
- Association between COL1A1 polymorphisms and high myopia: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Evaluation of MYOC, ACAN, HGF, and MET as candidate genes for high myopia in a Han Chinese population.Genetic testing and molecular biomarkers · 2014Article
- Myopia and diabetes mellitus as modificatory factors of glaucomatous optic neuropathy.Japanese journal of ophthalmology · 2014Review
- Whole genome expression profiling of normal human fetal and adult ocular tissues.Experimental eye research · 2013Article
- Experimental murine myopia induces collagen type Iα1 (COL1A1) DNA methylation and altered COL1A1 messenger RNA expression in sclera.Molecular vision · 2012Article
- Nature and nurture: the complex genetics of myopia and refractive error.Clinical genetics · 2011Review
- Risk factor analysis of 167 patients with high myopia.International journal of ophthalmology · 2010Article
- Myopia genetics: a review of current research and emerging trends.Current opinion in ophthalmology · 2009Review
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Authors and funding
17 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the association between genetic variants in myocilin and collagen type I alpha 1 genes and high myopia in an isolated island population.
methodsA total of 944 examinees from the genetic epidemiology study conducted on the island of Korcula, Croatia, were included in the study. We selected 2 short nucleotide polymorphisms (SNP) available in our genome-wide scan set of SNPs that were previously associated with high myopia and used them to replicate previous claims of possible association.
resultsNineteen cases of high myopia, defined as the refraction of </=-6.00 diopters, were identified and included in the analysis. We showed that rs2075555 in the COL1A1 gene was not associated with high myopia. In contrast, rs2421853 in the myocilin gene was significantly associated in both bivariate (P=0.006) and age- and sex-adjusted analysis (P=0.049).
conclusionMyocilin seems to be a very strong candidate for explaining some of the pathophysiological pathways leading to the development of both glaucoma and high myopia. As our finding was obtained in a relatively under-powered sample, further research and replication of these results is needed.
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