ArticleInterdisciplinary perspectives on infectious diseases2008
Combining microarray technology and molecular epidemiology to identify genes associated with invasive group B streptococcus.
Article in Interdisciplinary perspectives on infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Emerging fluoroquinolone resistance in Streptococcus agalactiae in South Korea.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Identification of a novel keyhole phenotype in double-disk diffusion assays of clindamycin-resistant erythromycin-sensitive strains of Streptococcus agalactiae.Microbial drug resistance (Larchmont, N.Y.) · 2011Article
- Prevalence of Haemophilus influenzae type b genetic islands among clinical and commensal H. influenzae and H. haemolyticus isolates.Journal of clinical microbiology · 2010Article
- Changing molecular epidemiology of group B streptococcus in Korea.Journal of Korean medical science · 2010Article
- Analysis of the genome content of Lactococcus garvieae by genomic interspecies microarray hybridization.BMC microbiology · 2010Article
- High-throughput molecular determination of salmonella enterica serovars by use of multiplex PCR and capillary electrophoresis analysis.Journal of clinical microbiology · 2009Article
- Comparison of probe hybridization array typing to multilocus sequence typing for pathogenic Escherichia coli.Journal of clinical microbiology · 2009Article
- Streptococcus Agalactiae Carriage, Serotype Distribution and Associated Antibiogram among Pregnant and Non-pregnant Women in Jos City, Nigeria.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Many bacterial species function as both commensals and pathogens; we used this dual nature to develop a high-throughput molecular epidemiological approach to identifying bacterial virulence genes. We applied our approach to Group B Streptococcus (GBS). Three representative commensal and one invasive GBS isolates were selected as tester strains from a population-based collection. We used microarray-based comparative genomic hybridization to identify open reading frames (ORFs) present in two sequenced invasive strains, but absent or divergent in tester strains. We screened 23 variable ORFs against 949 GBS isolates using a GBS Library on a Slide (LOS) microarray platform. Four ORFs occurred more frequently in invasive than commensal isolates, and one appeared more frequently in commensal isolates. Comparative hybridization using an oligonucleotide microarray, combined with epidemiologic screening using the LOS microarray platform, enabled rapid identification of bacterial genes potentially associated with pathogenicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.