ArticleGastrointestinal cancer research : GCR2008
Prognostic factors for squamous cell cancer of the anal canal.
Article in Gastrointestinal cancer research : GCR, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prognostic factors for patients with anal cancer treated with conformal radiotherapy-a systematic review.BMC cancer · 2022Pooled it
- Prognostic Significance of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography in Anal Squamous Cell Carcinoma: A Systematic Review and a Meta-Analysis.Contrast media & molecular imaging · 2018Pooled it
- Prognostic biomarkers in squamous cell carcinoma of the anus: a systematic review.British journal of cancer · 2010Pooled it
- Factors Influencing Outcomes and Survival in Anal Cancer.Current oncology (Toronto, Ont.) · 2024Article
- Ectopic production of beta-hCG in anal cancer: A case report.Clinical case reports · 2024Article
- Influence of radiation treatment technique (IMRT vs. 3D-RT) on acute toxicity and prognostic factors for survival for anal cancer.Scientific reports · 2022Article
- Leukocyte subtyping predicts for treatment failure and poor survival in anal squamous cell carcinoma.BMC cancer · 2022Article
- Racial/Ethnic Disparities in Survival Among Women Diagnosed with Invasive Cancer of the Anal Canal: an Analysis of Surveillance, Epidemiology, and End Results (SEER) Data.Journal of gastrointestinal cancer · 2021Article
- Role of Immune Checkpoint Inhibitors in Gastrointestinal Malignancies.Journal of clinical medicine · 2020Review
- Anal squamous cell carcinoma with metastasis to duodenum causing duodenal stricture and gastric outlet obstruction.AME case reports · 2019Article
- Efficacy and tolerance of high-dose-rate brachytherapy boost after external radiotherapy in the treatment of squamous cell carcinoma of the anal canal.Journal of contemporary brachytherapy · 2018Article
- The effect of dose escalation for large squamous cell carcinomas of the anal canal.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2018Article
- Biomarkers in anal cancer: from biological understanding to stratified treatment.British journal of cancer · 2017Review
- Genital invasion or perigenital spread may pose a risk of marginal misses for Intensity Modulated Radiotherapy (IMRT) in anal cancer.Radiation oncology (London, England) · 2016Article
- HIV positivity but not HPV/p16 status is associated with higher recurrence rate in anal cancer.Journal of gastrointestinal cancer · 2013Article
- [Curative radiotherapy in patients with anal cancer: clinical outcomes and prognostic factors in a single-institution experience].La Radiologia medica · 2013Article
- High survivin expression as a risk factor in patients with anal carcinoma treated with concurrent chemoradiotherapy.Radiation oncology (London, England) · 2012Article
- Intensity-modulated radiation therapy for the treatment of squamous cell anal cancer with para-aortic nodal involvement.International journal of radiation oncology, biology, physics · 2009Article
- Cancer and lesbian, gay, bisexual, transgender/transsexual, and queer/questioning (LGBTQ) populations.CA: a cancer journal for cliniciansReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiotherapy with concurrent chemotherapy is the standard of care for patients with nonmetastatic squamous cell anal cancer. Most patients treated with chemoradiotherapy have an excellent prognosis. However, some heterogeneity exists among anal cancer patients in their outcomes. This article reviews some of the clinical factors, treatment-related factors, and biologic factors that affect outcomes in patients with squamous cell anal cancer. The most important prognostic factors are the T and N stages. Some studies have suggested that women have better prognosis than men. Histologic subtypes and grade do not have a clear prognostic role. Response to treatment and duration of radiotherapy are likely to be important prognostic factors. Some molecular markers such as p53, p21, and cyclin A expression may have prognostic significance, but their role needs to be studied further. A better knowledge of prognostic factors could help us develop individualized therapies for patients and select high-risk patients for more aggressive and innovative treatments. A better understanding of molecular biology is required to characterize the inherent heterogeneity of anal cancer and thereby develop optimal therapies.
Identifiers
19259318PMC2630809What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.