ArticleGastrointestinal cancer research : GCR2008
Cancer stem cells, endothelial progenitors, and mesenchymal stem cells: "seed and soil" theory revisited.
Article in Gastrointestinal cancer research : GCR, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Cancer stem cell assay-guided chemotherapy improves survival of patients with recurrent glioblastoma in a randomized trial.Cell reports. Medicine · 2023Trial
- ChemoID-guided therapy improves objective response rate in recurrent platinum-resistant ovarian cancer randomized clinical trial.NPJ precision oncology · 2025Article
- Operative planning for a functional precision medicine assay of recurrent high-grade glioma: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- microRNA-26a represses pancreatic cancer cell malignant behaviors by targeting E2F7.Discover oncology · 2021Article
- The First Study Evaluating the Safety of Pre-Surgery Administration of Metformin in Patients with Colorectal and other Gastrointestinal Cancers and Effect on Cancer Stem Cells.Cancer medicine journal · 2021Article
- Mesenchymal stem cells maintain the stemness of colon cancer stem cells via interleukin-8/mitogen-activated protein kinase signaling pathway.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Wnt-Responsive Stem Cell Fates in the Oral Mucosa.iScience · 2019Article
- A biotherapy based on PSCs-in-3D spheroid-ameliorated biologics depletes in vivo cancer-sustaining stem cells.Oncotarget · 2015Article
- Natriuretic peptide receptor A signaling regulates stem cell recruitment and angiogenesis: a model to study linkage between inflammation and tumorigenesis.Stem cells (Dayton, Ohio) · 2013Article
- Role of treatment in the appearance and selection of BCR-ABL1 kinase domain mutations.Molecular diagnosis & therapy · 2012Article
- Proteomic definitions of mesenchymal stem cells.Stem cells international · 2011Article
- Rational therapeutic options for patients with myeloproliferative neoplasms.Transactions of the American Clinical and Climatological Association · 2011Review
- The Roles of MicroRNAs in the Cancer Invasion-Metastasis Cascade.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2010Article
- Colon cancer stem cells: a new target in the war against cancer.Gastrointestinal cancer research : GCR · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Isolation of putative cancer stem cells (CSCs) in various tumors has generated much excitement among researchers who consider these cells the potential "culprits" behind resistance to conventional therapy. Both cancer and cardiovascular disease are believed to be stem cell disorders involving circulating endothelial progenitors (CEPs) and mesenchymal stem cells (MSCs). CD133 and CD44, markers of CSCs in many tumors, also enrich CEPs and MSCs, respectively. We propose an integrated tumorigenesis model that involves all three interdependent stem cell (CSC, CEP, MSC) compartments by revisiting the "seed and soil" model. Developing therapeutics that can effectively target CSCs and spare normal cardiovascular tissue will remain a challenge. Preliminary laboratory and clinical data on monitoring and targeting colon CSCs, using such a modeling system, are discussed.
Identifiers
19259284PMC2632830W2411769793What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.